Background: Enhanced recovery after thoracic surgery (ERATS) protocols use a combination of analgesics for pain control. We investigated the effect non-steroidal analgesic drugs (NSAIDs) on control by comparing patient levels and opioid requirements robotic pulmonary resections.

Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, prolong the circulation time of various drugs. SLNs applied in oral, parenteral, transdermal, intranasal, ocular, pulmonary drug delivery different drugs, with enhanced safety, bioavailability, overall th...

BACKGROUND AND OBJECTIVE A substantial number of patients report pain after graft harvest from the anterior iliac crest. This study examined the efficacy of local application of bupivacaine soaked in a Gelfoam(®) at the bone donor site in controlling postoperative pain and parenteral opioid use. METHOD We performed a prospective, double-blind, randomized, placebo-controlled study comparing in...

Chemotherapy-induced nausea and vomiting are defined as the most common of side effects treatment and, at same time, very difficult to accept for patients’, frequently causing changes in therapy regimen, significantly reducing its effectiveness. Thus, an antiemetic prophylactic is essential provision such a patient. Pharmacotherapy often includes various drugs, including antiemetics, with admin...

Sağlık hizmeti verilen birimlerde parenteral ilaç uygulamalarında cam ampul formu ilaçlar sıklıkla kullanılmaktadır. Tedavi sırasında bu form hazırlanırken ampulun boyun kısmından kırılması sonucunda çok sayıda mikro ve makro boyutlarda partikül oluşmaktadır. Bu parçacıkların içerisine dökülmesi ile ilacın kontaminasyonu gerçekleşmektedir. Kontamine olan yollarla hastalara enjekte edildiğinde t...

In Australia and New Zealand, in parallel with other developed countries, the number of patients prescribed opioids on a long-term basis has grown rapidly over the last decade. The burden of chronic pain is more widely recognised and there has been an increase in the use of opioids for both cancer and non-cancer indications. While the prevalence of illicit opioid use has remained relatively sta...

Over the course of 1 to 2 years, the field has moved swiftly to investigate the functional and structural properties of the newly cloned opioid receptors. Achieving a better understanding of these macromolecules is likely to have profound implications for drug design aimed at the production of better analgesic drugs, for a more fundamental understanding of mechanisms of action of drugs of abuse...

OBJECTIVE This is a retrospective study of the role of postoperative epidural analgesia in major spinal surgical procedures. With the number and complexity of the procedures performed on the spine ever-increasing, this method of analgesia is becoming more important. METHODS Results of 74 consecutive cases of major spinal surgeries between January 2000 and January 2001 at the Spine Division, A...