Background: Recent evidence suggests that regular exercise training is effective in treating various aspects of cancer. Therefore, the purpose of this study was to determine the effect of 8 weeks of aerobic interval training on monocarboxylate transporter 1 (MCT1) protein and expression of p53 gene in tumor of colon cancer mice. Methods: The present study was conducted experimentally from May ...

the most frequently mutated tumor suppressor gene found in human cancer is p53. in a normal situation, p53 is activated upon the induction of dna damage to either arrest the cell cycle or else induce apoptosis. however, when mutated, p53 is no longer able to properly accomplish these functions. our aim was to investigate p53 protein alteration in cases of basal cell carcinoma (bcc) and compare ...

Background: Progesterone receptor (PR), estrogen (ER) expression, human epidermal growth factor 2 (HER neu) amplification/ overexpression, and p53 nuclear protein accumulation are all significant prognostic biomarkers in breast cancer (BC). This work aims to assess the co-presence of overexpression with ER, PR, HER neu expression invasive BC specimens by IHC compare their various clinicopatholo...

MicroRNAs (miRNAs) are involved in the initiation and development of cancer participate drug resistance. Paclitaxel (PTX) is a first-line chemotherapy for advanced non-small cell lung (NSCLC). The abnormal miRNA expression NSCLC its association with resistance remains largely unknown. study aimed to investigate aberrant miR-221–3p elucidate molecular mechanisms relation PTX increased regulated ...

The Effect of Endurance Training with Nano-Curcumin Supplementation on p53-p21 Axis and TERF2 Gene Expression in Muscle Tissue Male Wistar Rats: An Experimental Study

p53 is a key tumor suppressor gene that is targeted for inactivation during human tumorigenesis. In this study, we produced and characterized polyclonal antihuman p53 antibody. The cDNA encoding the completehuman p53 protein was cloned into pGEX-4T-1 and expressed in Escherichia coli as a fusion protein with Schistosoma japonicum glutathione S-transferase (GST). The rabbits were immunized...

Elevated cAMP levels in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells attenuate the doxorubicin-induced p53 accumulation and protect cells against apoptosis. cAMP responsive element binding protein (CREB) is a cAMP-stimulated transcription factor that regulates genes whose deregulated expression cooperatein oncogenesis. In the present study, we investigated the role of CREB on i...

introduction: colorectal carcinoma is a main health problem in many countries and the third common cancer in iran. this malignancy at present is the most curable carcinoma of gastrointestinal tract. variation in the expression of the proteins produced by p53, p21, p16, e-cadherin, and β-catenin genes have been noted in this malignancy and may be important in the prognosis and therapeutic respon...

Background: The survival of patients with triple-negative breast cancer subtype undergoing chemotherapy along weight management, physical activity, and diet was examined. In addition, the relationship between Overall Survival (OS) expression P53 Ki 67 investigated. Methods: study conducted on 110 admitted to oncology clinics October 2009 July 2018. underwent five cycles, including Docetaxel, Ep...