ernment and College of Physicians and Surgeons of Saskatchewan after it was unable to collect a $2.2-million negligence award because the physician involved had no malpractice insurance. Alana Marble suffered permanent brain damage in 1992 at the Kindersley Union Hospital in southwestern Saskatchewan. Her parents, John and Maureen Marble, initially sued the hospital and several physicians and n...

Abstract It is generally expected that biotransformation and excretion of pharmaceuticals occurs similarly in fish mammals, despite significant physiological differences. Here, we exposed European perch (Perca fluviatilis) to the benzodiazepine drug temazepam at a nominal concentration 2 µg L?1 for 10 days. We collected samples blood plasma, muscle, brain time-dependent manner assess its biocon...

Using capillary electrophoresis combined with tandem mass spectrometry, we have developed a method to simultaneously detect lorazepam, clonazepam, temazepam, oxazepam, diazepam, and nitrazepam in urine. The urine samples were submitted to a modified QuEChERS extraction procedure, followed by electrophoretic separation in 0.1 M formic acid electrolyte (pH 2.4) using a polyvinyl alcohol (PVA)-coa...

We compare measurement of the tricyclic antidepressants desipramine, imipramine, nortryptaline, and amitryptaline by reversed-phase "high-performance" liquid chromatography and by gas chromatography/mass fragmentography. The liquid-chromatographic procedure does not require ion-pairing reagents, and involves detection at 215 nm. The within-day and between-day CVs for this method were less than ...

The role of the chemical properties Pharmaceutically Active Compounds (PhACs) in their sorption behaviour and consequently fate mobility is major environmental interest, but a comprehensive evaluation still lacking. nine PhAC molecules with distinct physico-chemical on soils goethite was described using linear, Freundlich Langmuir models relationship between structures compounds parameters adso...

We present a general overview of the drug-facilitated sexual assault phenomenon in the United States sexual abuse of both women and men, while under the influence of so-called “date-rape” drugs, has been the focus of many investigations. Throughout the 1990s, an alarming increase in anecdotal reports of this crime as well as in the number of scientific publications on drug-facilitated sexual as...

The goal of the present study was to separate a set of benzodiazepines, namely bromazepam, oxazepam, nitrazepam, chlordiazepoxide, flunitrazepam, lormetazepam and diazepam by analytical scale HPLC and CZE. The both methods for separation of these seven compounds from the 1,4-benzodiazepine group were optimized and compared. LODs and LOQs were determined under the optimized conditions in the bot...

BACKGROUND Often, long-term treatment with benzodiazepines is a subject of discussion due to potential side effects, with dependence on benzodiazepines as the most serous one. After longer period of benzodiazepines tolerance on their anxiolytic effects develops. Discontinuation is usually beneficial as it is followed by improved psychomotor and cognitive functioning, particularly in the elderly...