Abstract Background Epigenome-wide association studies (EWAS) and differential gene expression analyses are generally performed on tissue samples, which consist of multiple cell types. Cell-type-specific effects a trait, such as disease, the omics interest but difficult or costly to measure experimentally. By measuring data for bulk tissue, type composition sample can be inferred statistically....

OBJECTIVE To assess the ability of nonlinear optical microscopy (NLOM) to image ex vivo healthy and degenerative bovine articular cartilage. METHOD Fresh bovine femoral-tibial joints were obtained from an abattoir. Articular cartilage specimens were harvested from the tibial plateau. Normal and degenerative specimens were imaged by NLOM and subsequently fixed and processed for histological ex...

Progress in imaging and quantification of tissue perfusion using ultrasound (US) and microbubble contrast agents has been undermined by the lack of an effective automatic attenuation correction technique. In this article, an elementary model of the US attenuation processes for microbubble contrast enhanced imaging is developed. In the model, factors such as nonlinear bubble scattering, nonlinea...

Introduction. Adipose tissue is the largest endocrine organ, composed of subcutaneous (SAT) and visceral adipose tissue (VAT), the latter being highly associated with coronary artery disease (CAD). Expansion of epicardial adipose tissue (EAT) is linked to CAD. One way of assessing the CAD risk is with low-cost anthropometric measures, although they are inaccurate and cannot discriminate between...

The Keller-Segel model is a well-known system representing chemotaxis in living organisms. We study the convergence of generalized nonlinear variant to degenerate Cahn-Hilliard system. This analysis made possible from observation that equivalent relaxed version Furthermore, this latter has an interesting application modelling tissues. Indeed, compressible and incompressible porous medium type e...

In medical diagnostic ultrasound (US), higher than-in-water nonlinearity of body fluids and tissue usually does not produce strong nonlinearly distorted waves because of the high absorption. The relative influence of absorption and nonlinearity can be characterized by the Gol'dberg number Gamma. There are two limiting cases in nonlinear acoustics: weak waves (Gamma < 1) or strong waves (Gamma >...

bone tissue engineering has been one of the most promising areas of research, providing a potential clinical application to cure bone defects. recently, various stem cells, including embryonic stem cells (escs), bone marrow-derived mesenchymal stem cells (bm-mscs), umbilical cord blood-derived mesenchymal stem cells (ucb-mscs), adipose tissue-derived stem cells (adscs), muscle-derived stem cell...

background and aims. furcally-involved teeth present unique challenges to the success of periodontal therapy and influence treatment outcomes. this study aimed to assess to compare use of adm and connective tissue membrane in class ii furcation defect regeneration. materials and methods. 10 patient with 2 bilaterally class ii furcation defects in first and/or second maxilla or man-dibular molar...

lipoma is the most common soft tissue tumor but the presence of osseous component within the tumor is quite rare. some studies show that less than 1% of lipomas were ossified. we describe the histological, radiological and diagnostic features of an ossified intramuscular lipoma. to the best of the authors' knowledge, a symptomatic ossified intramuscular lipoma without any cortical erosion and h...