نتایج جستجو برای: neurotoxicity syndromes

تعداد نتایج: 85645  

Journal: :Toxicology and applied pharmacology 2007
Michael Aschner Tomás R Guilarte Jay S Schneider Wei Zheng

The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicit...

Journal: :Behavioral neuroscience 2014
Genieve Peckford Jessica A Dwyer Anna C Snow Christina M Thorpe Gerard M Martin Darlene M Skinner

To investigate the role of the head direction (HD) cell circuit in spatial navigation, rats with bilateral, neurotoxic lesions to the postsubiculum (PoS; Experiment 1) or the anterior dorsal nucleus of the thalamus (ADN; Experiment 2) were compared to sham controls on 2 tasks that could be solved using directional heading. Rats were first trained on a direction problem in a water T maze where t...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2012
Jeffry D Schroeter David C Dorman Miyoung Yoon Andy Nong Michael D Taylor Melvin E Andersen Harvey J Clewell

Manganese (Mn) is an essential element that is neurotoxic under certain exposure conditions. Monkeys and humans exposed to Mn develop similar neurological effects; thus, an improved understanding of the dose-response relationship seen in nonhuman primates could inform the human health risk assessment for this essential metal. A previous analysis of this dose-response relationship in experimenta...

Journal: :Environmental Health Perspectives 1996
H A Tilson R C MacPhail K M Crofton

Increased emphasis on routine screening of chemicals for potential neurotoxicity has resulted in the development of testing guidelines and standardized procedures. A multiphased, tiered-testing strategy has been proposed by numerous expert panels to evaluate large numbers of chemicals. In a regulatory context, however, a formal tiered-testing approach is not used, mostly because of the constrai...

2009
Anna Fernández Laura Llacuna José C. Fernández-Checa Anna Colell

Anna Fernández,1,2,3,4 Laura Llacuna,1,2,3,4 José C. Fernández-Checa, 1,2,3,4* and Anna Colell1,2,3,4* 1Department of Cell Death and Proliferation, Institut d’Investigacions Biomèdiques de Barcelona, Consejo Superior de Investigaciones Científicas and Unidad de Hepatologı́a, Hospital Clinic i Provincial, 2Centro de Investigaciones Biomédicas Esther Koplowitz, 3Centro de Investigación Biomédica e...

Journal: :AJNR. American journal of neuroradiology 1999
S C Coley D A Porter F Calamante W K Chong A Connelly

Apparent diffusion coefficient maps of two patients with cyclosporine-induced neurotoxicity showed areas of increased diffusion that corresponded to the characteristic regions of signal change on routine T2-weighted sequences. The majority of lesions subsequently resolved without residual T2 or diffusion signal alteration. These findings suggest that, in our patients, the neurotoxic effects of ...

Journal: :Canadian journal of public health = Revue canadienne de sante publique 2010
Melissa Legrand Mark Feeley Constantine Tikhonov Deborah Schoen Angela Li-Muller

Exposure to methylmercury (MeHg) from fish and marine mammal consumption continues to present a public health concern. To date, developmental neurotoxicity is the most sensitive health outcome, forming the basis for health-risk assessments and the derivation of biomonitoring guidance values. This article summarizes existing Health Canada MeHg blood guidance values for general population and exp...

Journal: :The Yale Journal of Biology and Medicine 1978
Terri Damstra

Selected examples of associations between nervous system diseases and exposures to occupational and environmental chemicals have been reviewed. Recent outbreaks of human neurotoxicity from both wellknown and previously unknown toxicants reemphasize the need for the medical community to give increased attention to chemical causes of nervous system dysfunction.

Journal: :Neurotoxicology 2012
Donna Mergler

Although males and females differ both biologically and in their social and power relations throughout their life span, research in environmental and occupational neurotoxicology often ignore sex and/or gender as a characteristic that requires in-depth consideration. The neurotoxicology literature continues to confuse the terms sex (biological attributes) and gender (socially constructed roles ...

2017
Aurora Armiento Philippe Moireau Davy Martin Nad'a Lepejova Marie Doumic Human Rezaei

In mammals, Prion pathology refers to a class of infectious neuropathologies whose mechanism is based on the self-perpetuation of structural information stored in the pathological conformer. The characterisation of the PrP folding landscape has revealed the existence of a plethora of pathways conducing to the formation of structurally different assemblies with different biological properties. H...

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