Multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. Many studies have shown that inflammation causing neuronal demyelination. MS is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. Platelet activating fact...

Objective(s): Neurotrophins (NTs) exert various effects on neuronal system. Growing evidence indicates that NTs are involved in the pathophysiology of neuropathic pain. However, the exact role of these proteins in modulating nociceptive signaling requires being defined. Thus, the aim of this study was to evaluate the effects of spinal nerve ligation (SNL) on NTs activation in the lumbar dorsal ...

Background Nerve blood flow has a critical role in acute and chronic pathologies in peripheral nerves. Influences of local anesthetics and adjuvants on tissue perfusion and oxygenation are deemed as relevant factors for nerve damage after peripheral regional anesthesia. The link between low tissue perfusion due to local anesthetics and resulting tissue oxygenation is unclear. Methods Combined...

Perineural invasion is an underrecognized route of metastatic spread along the nerve bundles within the nerve sheath into the surrounding tissues. It hinders the ability to establish local control as tumour cells can traverse along nerve tracts well beyond the extent of any local invasion rendering them inoperable and unresectable. Perineural invasion is a marker of poor prognosis. Oral submuco...

Inflammatory conditions intensify and then resolve, often sparing and recovering some of the injured tissue. While the ebb and flow of inflammation can be followed in many tissues, there is not a great deal of information on how inflammation regresses in the brain. In this issue of the JCI, Walsh, Hendrix, and colleagues illuminate a cellular mechanism whereby T cells that infiltrate the brain ...

Tissue Adhesives In article number 2105338, Donghee Son, Changhyun Pang, and co-workers report an electrostatic–mechanical synergistic multiscale tissue adhesive for sustainable residue-free bioelectronics interfaces. To deduce the mechanism, a thermodynamic model based on tailored elastomer–hydrogel combinatory architecture is proposed. This patch also successfully demonstrates reliable real-t...

Introduction The pathway of a pain impulse starts with the primary afferent nerve fibers (C and Aδ) whose axons end in the dorsal horn of the spinal cord. Nociceptive information is passed to the contralateral side of the spinal cord and, after synapsing, ascends in the anterolateral system as spinothalamic tracts. The primary areas of the brain that respond to pain stimuli are the somatosensor...

In the process of neuronal inflammation, an increased in inflammatory cytokines (IL-1β, IL-6 and TNF-α) from immune cells (leukocytes and macrophages), brain cells (microglia, astrocytes and neurons) and in hippocampus, amygdala occurs. Raise the level of cytokines result in reduced in production of molecules that are related to plasticity, especially BDNF, IGF-1 and VEGF. Microglia ...

The goal of ultrasound-guided suprainguinal fascia iliaca block (USG-SFIB) is anesthetic spread to three nerves, which are lateral femoral cutaneous nerve (LFCN), (FN), and obturator (ON). 90 % minimum effective volume (MEV90) for USG-SFIB each result studied showed the successful effect in various block. So, Thus, study purposes demonstrate efficiency (MEV90,62.5 ml) confirm staining dye conne...