Human paraoxonase-1 (HuPON1) has been proposed as a catalytic bioscavenger of organophosphorus (OP) pesticides and nerve agents. We assessed the potential of this enzyme to protect against OP poisoning using two different paradigms. First, recombinant HuPON1 purified from cabbage loopers (iPON1; Trichoplusia ni) was administered to guinea pigs, followed by exposure to at least 2 times the media...

conclusions our results support the use of pns in some patients with refractory chronic headaches. appropriate surgical planning and technique are important to achieve good clinical outcome and to minimize complications. background subcutaneous peripheral nerve stimulation (pns) has emerged as a useful tool in the treatment of intractable headaches. however, complications such as skin erosion, ...

background: two main muscles studied in the hand for evaluation of median nerve injuries are opponens pollicis (op) and abductor pollicis brevis (apb). however, riché-cannieu communicating branch (rccb) may limit the use of these muscles in electrodiagnosis. this condition is confusing in the case of median nerve injuries. this study was conducted to evaluate the prevalence of rccb.   methods: ...

www.aana.com/aanajournalonline.aspx Despite numerous medications designed to eliminate or decrease seizures, an estimated 20% of epileptic patients in the United States remain refractory to these agents. Vagal nerve stimulation can decrease the number of seizure episodes. In 1997, the US Food and Drug Administration approved the first implantable stimulation device for the treatment of medicall...

A good knowledge of the basic mechanisms of acute toxicity of organophosphorus compounds has lead to the development of specific antidotes able to counteract their acute toxic effects. Unfortunately, there are still some highly toxic organophosphorus compounds, called nerve agents, that are resistant to standard antidotal treatment. Relatively unsatisfactory antidotal treatment of acute poisoni...

AIMS We investigated the invitro effects of local anesthetics on the contractility of the human bladder. METHODS By measuring the invitro isometric contractions of human bladder strips, we determined the effects of tetracaine, bupivacaine, lidocaine, and ropivacaine on the basal spontaneous contractions and contractions induced by various stimuli, namely, KCl (60 mM), carbachol (CCh), and ele...