The ionophoretic antibiotics, monensin and lasalocid, bind numerous mono- and divalent cations, primarily in dimeric complexes that facilitate the passage of metal ions through hydrophobic lipid membranes. Ionophores vary in their affinity for metal ions. Similarly, transport rates of the resulting complexes depend in part upon the affinity constant of the drug ion-binding interaction, and in p...

Introduction Ionophores have been used extensively in the beef industry in Canada since 1977. Until recently, there has been no label indication for use of ionophores in lactating dairy cattle. Ionophores are feed additives that alter rumen microbial populations through ion transfer across cell membranes. In Canada, the label warning prohibiting the use of Rumensin premix in lactating dairy ca...

The global emergence of drug resistance in malaria is impeding the therapeutic efficacy of existing antimalarial drugs. Therefore, there is a critical need to develop an efficient drug delivery system to circumvent drug resistance. The anticoccidial drug monensin, a carboxylic ionophore, has been shown to have antimalarial properties. Here, we developed a liposome-based drug delivery of monensi...

Kalal!njuk G. I., M. Marounek, M. G. Gerasymiv, O. G. Savka, L. G. Kalal!njuk: Activity of Dehydrogenases and Enzymes of Nitrogen Metabolism in Rumen Mucosa and Liver of Steers Fed Monensin. Acta vet. Bmo, 62, 1993: 127-131. The effect of monensin on activity of intracellular enzymes of tissues was determined in ten steers fed hay, silage and concentrate. Five steers received monensin in amount...

Incubation of mouse thymocytes with 10 microM monensin for 1 hour induces morphological alterations characterized by the extensive dilatation and vacuolization of the Golgi complex. This effect is used to study the transport and utilization of labelled sugar nucleotides into intracellular vesicles by using thymocytes whose plasma membrane has been permeabilized by ammonium chloride treatment. I...

Treatment of short-term monolayer cultures of rat hepatocytes with the proton ionophore, monensin, abolishes asialoglycoprotein degradation, despite little effect of the drug on either surface binding of ligand or internalization of prebound ligand. Centrifuging cell homogenates on Percoll density gradients indicates that, as a result of monensin treatment, ligand does not enter lysosomes but s...

Current treatment options for advanced and hormone refractory prostate cancer are limited and responses to commonly used androgen pathway inhibitors are often unsatisfactory. Our recent results indicated that sodium ionophoremonensin is one of themost potent and cancer-specific inhibitors in a systematic sensitivity testing of most known drugs and drug-like molecules in a panel of prostate canc...

The aim of the present study was to investigate the efficacy of monensin sodium grain size on controlling coccidiosis in broiler chickens. Three hundred and fifty Cobb 700 chicks were infected experimentally with 8 × 10(4) sporulated oocysts of Eimeria spp. The birds were fed with diets supplemented with powdered (n = 150) or granulated (n = 150) monensin, with particle sizes of ≤ 100 µm and 45...

In HeLa cells exposed to supra-optimal temperatures, the alpha-crystallin-related stress protein hsp28 is reversibly redistributed inside the nucleus and increases its level of phosphorylation and aggregation. Here, I show that, at normal temperature after a heat stress, the sodium ionophore monensin maintains the nuclear localization of hsp28 without impairing the dephosphorylation of this pro...

This study was designed to evaluate the potential application of monensin as an oral drug for the treatment of cadmium-induced hepatic dysfunction. The study was performed using ICR mouse model. Twenty-seven adult ICR male mice were divided into three groups of nine animals each: control (received distilled water and food ad libitum for 28 days); Cd-intoxicated (treated orally with 20 mg/kg b.w...