نتایج جستجو برای: microglobulin

تعداد نتایج: 3712  

Journal: :Annals of the rheumatic diseases 1986
J McClure C J Bartley P Ackrill

Three patients receiving long term haemodialysis treatment for chronic renal failure due to non-amyloid nephropathy developed the carpal tunnel syndrome requiring decompression surgery. The excised material contained amyloid, which by immunocytochemical techniques was shown to contain beta 2 microglobulin. This is, therefore, a new chemical form of amyloid whose deposition is likely to be the c...

Journal: :Mechanisms of Development 2002
Diego Sánchez Salvador Martı́nez Annika Lindqvist Bo Åkerström Cecilia Falkenberg

The expression pattern of the alpha(1)-microglobulin/bikunin precursor (AMBP) gene, and its two protein products were studied in mouse embryos of 8.5-15.5 days of embryonic development by in situ hybridization and immunohistochemistry. AMBP mRNA is strongly transcribed in liver parenchyma, pancreas, and intestine epithelium. Sites of weaker expression are the vessels of the umbilical cord, the ...

Journal: :The Journal of Experimental Medicine 1978
M Fellous E Günther R Kemler J Wiels R Berger J L Guenet H Jakob F Jacob

The expression of the H-Y antigen has been tested on several human lymphoid lines and mouse teratocarcinoma cell lines during differentiation. The human male lymphoid cell line Raji is a very useful target for studies of the H-Y antigen by lymphocytotoxicity test with rat anti-H-Y sera. With a few exceptions, all cells carrying the Y chromosome were H-Y positive. One of the exceptions is the hu...

Journal: :International journal of clinical and diagnostic pathology 2023

Background: A subgroup of T and B cells express the extracellular enzyme cluster differentiation (CD73), which hydrolyzes adenosine monophosphate to adenosine. This work aimed evaluate CD73 expression its correlation with other disease characteristics in leukemia chronic lymphocytic type (CLL) patients. Methods: cross-sectional research was done on 30 CLL cases diagnosed by laboratory investiga...

Journal: :Journal of insurance medicine 1994
J Boffa

Beta-2 microglobulin is a sensitive surrogate test for HIV infection for use in jurisdictions where HIV antibody tests are not allowed to be performed on life insurance applicants by law/regulation. The advantage of beta-2 microglobulin over T cell testing, which is a surrogate test also used by the life insurance industry for detecting HIV infection, is the stability of B 2M in serum over lon...

Journal: :The Medical journal of Malaysia 2000
C Y Hong K S Chia S L Ling

BACKGROUND Urinary excreton of low molecular weight proteins such as beta2-microglobulin and retinol binding protein (RBP), and enzymes such as N-acetyl-beta-D-glucosaminidase (NAG), may be useful as indicators of renal tubular dysfunction in diabetes mellitus. OBJECTIVE To describe the profile of urinary protein and enzyme excretion in 240 Chinese patients with type 2 diabetes mellitus in Si...

2014
Jia Hu Mei Li Tian-xu Han Jian-wei Chen Lin-xiang Ye Qi Wang Yi-kai Zhou

BACKGROUND A number of factors, including gender, age, smoking habits, and occupational exposure, affect the levels of urinary cadmium. Few studies have considered these influences when calculating the benchmark dose (BMD) of cadmium. In the present study, we aimed to calculate BMDs and their 95% lower confidence bounds (BMDLs) for cadmium-induced renal tubular effects in an age-specific popula...

2014
Jana Svatoňová Klára Bořecká Pavel Adam Věra Lánská

Beta2-Microglobulin ( β 2-m) is a low molecular weight protein occurring in all body fluids. Its concentration increases in various pathologies. Increased values in cerebrospinal fluid (CSF) are ascribed to an activation of immune system. Using immunoturbidimetry, we examined concentrations of beta2-microglobulin in cerebrospinal fluid in a large group of 6274 patients with defined neurological...

Journal: :International journal of clinical & laboratory research 2000
M A Fernández F Ruiz-Cabello M R Oliva T Cabrera P Jimenez M A López Nevot F Garrido

One hundred and sixty-two tumor samples were analyzed for HLA class I expression using immunohistological techniques. HLA class I total loss (phenotype no. I) was detected in 31 cases (19%), comprising 20 colorectal, 3 laryngeal, and 2 bladder carcinomas and 6 melanomas. Twenty-one cases were selected for molecular analysis due to a higher proportion of tumor cells versus stroma cells (75%). We...

Journal: :Proteomics. Clinical applications 2011
Olwyn Johnston Hilary Cassidy Séin O'Connell Aisling O'Riordan William Gallagher Patricia B Maguire Kieran Wynne Gerard Cagney Michael P Ryan Peter J Conlon Tara McMorrow

PURPOSE Chronic allograft nephropathy (CAN) remains the leading cause of renal graft loss after the first year following renal transplantation. This study aimed to identify novel urinary proteomic profiles, which could distinguish and predict CAN in susceptible individuals. EXPERIMENTAL DESIGN The study included 34 renal transplant patients with histologically proven CAN and 36 patients with ...

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