Several lines of evidence suggest that neuroinflammation might be a key neurobiological mechanism depression. In particular, the P2X7 receptor (P2X7R), an ATP-gated ion channel involved in activation pro-inflammatory interleukin IL-1?, has been shown to potential new pharmacological target The aim this study was explore impact unpredictable chronic mild stress (UCMS) on behavioural changes, hip...

Abstract Background Currently available PET tracers used in Alzheimer's disease (AD) have limited utility prognosis and revealing reliable clinicopathologic correlations of disease. Therefore, identification validation novel biomarkers for AD progression preclinical onset through noninvasive neuroimaging is a top priority biomedical research. We proposed to target microtubules (MTs) as an imagi...

Metronidazole is used to treat trichomoniasis, bacterial vaginosis, and other diseases. There are controversy aspects about its teratogenicity. A teratogenic agent can alter morphology or subsequent function of the fetus. The aim of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by Metronidazole usin...

introduction: kainic acid (ka) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (tle). according to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (se) induced by ka. this study aimed to quantitatively evaluate changes...

Abstract The Westernized diet refers to consuming high amounts of saturated fat, sugar, and salt, low dietary fiber. Such a is currently thought contribute non-communicable diseases such as autoimmune diseases, heart disease, cancer. A high-salt (HSD) known affect various organs, including the cardiovascular, renal, central nervous systems. Recently, several studies reported effect HSD on cance...

Background: Evidence supports a role for the gut-brain axis in Parkinson’s disease (PD). Mice overexpressing human wild type α– synuclein (Thy1-haSyn) exhibit slow colonic transit prior to motor deficits, mirroring prodromal constipation PD. Identifying molecular changes gut could provide both biomarkers early diagnosis and gut-targeted therapies prevent progression. Objective: To identify Thy1...

Abstract Treatment of brain tumors, epilepsy, or hemodynamic abnormalities requires a craniotomy to access the brain. Despite prophylaxis, infectious complications after range from 1–3% with approximately half caused by Staphylococcus aureus(S. aureus). Using our novel mouse model infection, critical role CD4 +T cells was established since bacterial burdens were significantly increased in brain...

Administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. In the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. Intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p<O.OOO 1). The u2- ad...

Objective(s) Previous studies have demonstrated that pretreatment with alpha-tocotrienol (a-TCT) can reduce ischemic damage in mice following middle cerebral artery (MCA) occlusion. It is also reported to decrease stroke- dependent brain tissue damage in 12-Lox-deficient mice and spontaneously hypertensive rats. In the present study, the neuroprotective effects of a-TCT and rosiglitazone (RGZ)...