نتایج جستجو برای: merrifield

تعداد نتایج: 202  

Journal: :ACS combinatorial science 2016
Doohyun Lee Seungyeon Lee Kwang-Hyeon Liu Jong-Sup Bae Dong Jae Baek Taeho Lee

Traceless solid-phase synthesis of 1,3,7,8-tetrasubstituted xanthine (1,3,7,8-tetrasubstituted 1H-purine-2,6(3H,7H)-dione) derivatives has been developed. The solid-phase synthetic route began on a solid supported N'-cyano-N-substituted carbamimidothioate, which was prepared from cyanamide, isothiocyanate, and Merrifield resin. After N-alkylation of carbamimidothioate resin with ethyl 2-bromoac...

Journal: :Nature chemistry 2017
Nikolaos G Engelis Athina Anastasaki Gabit Nurumbetov Nghia P Truong Vasiliki Nikolaou Ataulla Shegiwal Michael R Whittaker Thomas P Davis David M Haddleton

Translating the precise monomer sequence control achieved in nature over macromolecular structure (for example, DNA) to whole synthetic systems has been limited due to the lack of efficient synthetic methodologies. So far, chemists have only been able to synthesize monomer sequence-controlled macromolecules by means of complex, time-consuming and iterative chemical strategies such as solid-stat...

Journal: :FEBS letters 1979
G R Matsueda M N Margolies

The solid-phase Edman degradation procedure as proposed by Laursen [ 1] is ideally suited to the evaluation of peptidyl-resin products resulting from Merrifield solid-phase synthesis [2,3] of peptides. Incomplete deprotection and incomplete coupling reactions which occur during synthesis have been detected using quantitative Edman degradation [4,5]. However, extended sequencing experiments were...

Journal: :Journal of biochemistry and molecular biology 2005
Dong-Sik Shin Do-Hyun Kim Woo-Jae Chung Yoon-Sik Lee

Solid phase peptide synthesis method, which was introduced by Merrifield in 1963, has spawned the concept of combinatorial chemistry. In this review, we summarize the present technologies of solid phase peptide synthesis (SPPS) that are related to combinatorial chemistry. The conventional methods of peptide library synthesis on polymer support are parallel synthesis, split and mix synthesis and...

Journal: :Journal of combinatorial chemistry 2003
D Chávez A Ochoa D Madrigal M Castillo K Espinoza T González E Vélez J Meléndez J D García I A Rivero

A new approach on the use of mass spectrometry direct-insertion and a quadrupole detector for analysis of organic compounds supported in solid phase has been developed. This is a simple and efficient method based on cleavage due to the thermal-instability of the benzylic group of most commercial resins. The cleavage of supported compounds takes place in the spectrometer as a consequence of the ...

1986
EUGENE GARFIELD Herbert A. Hauptman

In last year’s examination of the 1984 Nobel laureates in physics and chemistw, 1 I noted that Carlo Rubbia, Harvard University and the European Center for Nuclear Research (CERN), Geneva, Switzerland, and Simon van der Meer, also of CERN, received the physics prize barely two years after they identified the W and Z subatomic particles. This is one of the shortest intervals between discovery an...

2012
Marcio Costa Sobral

Class III malocclusion is characterized by anterior posterior dental disharmony, either with or without skeletal discrepancies. Facial esthetics may be compromised to a greater or lesser degree, depending on the magnitude of the discrepancy, and is one of the main factors motivating individuals to seek orthodontic treatment. In adult patients, therapy may be performed by means of dental compens...

Journal: :Discrete Applied Mathematics 2007
Haizhen Ren Fuji Zhang

Double hexagonal chains” can be considered as benzenoids constructed by successive fusions of successive naphthalenes along a zig-zag sequence of triples of edges as appear on opposite sides of each naphthalene unit. In this paper, we discuss the numbers of k-matchings and k-independent sets of double hexagonal chains, as well as Hosoya indices and Merrifield–Simmons indices, and obtain some ex...

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