The aim of this investigation was to improve the dissolution properties of the water-insoluble drug ezetimibe (EZE) and potentially improve bioavailability. A combination of melt and adsorption techniques was employed for the preparation of solid dispersions. PEG 4000, PEG 6000, and Gelucire 44/14 were used as hydrophilic carriers, and lactose monohydrate was used as an adsorbent. Phase solubil...

The possibility of obtaining a filament for 3D printing from plastic bottles based on polyethylene terephthalate is investigated. A preliminary heat treatment the material proposed, which allows powder with minimal energy consumption dispersion. temperature regime processing an extrusion line single-screw extruder subsequent cooling melt before winding coils determined. Comparative strength tes...

Fuel cells constitute one of the most promising sources of clean energy for the 21 century and bipolar plate is an important component of a PEM fuel cell. Polymers filled with conducting fibers have been chosen as a candidate material for bipolar plates which needs to fulfill the surface conductivity requirement. In the present paper, effect of processing parameters including melt temperature, ...

The existence of partial melt is frequently invoked to explain geophysical anomalies such as low seismic wave velocity and high electrical conductivity. I review various experimental and theoretical studies to evaluate the plausibility of this explanation. In order for a partial melt model to work, not only the presence of melt, but also the presence of appropriate amount of melt needs to be ex...

[1] We explore possible models for the seismological signature of the oceanic lithosphere-asthenosphere boundary (LAB) using the latest mineral-physics observations. The key features that need to be explained by any viable model include (1) a sharp (<20 km width) and a large (5–10%) velocity drop, (2) LAB depth at ~70 km in the old oceanic upper mantle, and (3) an age-dependent LAB depth in the...

acrylamide was grafted in low density polyethylene during melt processing in the presence of a free radical initiator using a torque rheometer in a closed system. effects of processing time, acrylamide and benzoyl peroxide concentrations were studied. ftir studies revealed that the degree of grafting increased by an increase in acrylamide concentration. maximum grafting was obtained at 7 minute...

An advanced SiO2–lignin hybrid material was obtained and tested as a novel poly(vinyl chloride) (PVC) filler. The processing of compounds of poly(vinyl chloride) in the form of a dry blend with silica–lignin hybrid material and, separately, with the two components from which that material was prepared, was performed in a Brabender mixing chamber. An analysis was made of processing (mass melt fl...

OBJECTIVE The aim of this study was to evaluate the applicability of POVACOAT™, a hydrophilic PVA copolymer, as a solid dispersion (SD) carrier for hot-melt extrusion (HME). METHODS Bifendate (DDB), a water-insoluble drug, was chosen as the model drug. DDB was hot-melt extruded by a co-rotating twin screw extruder with POVACOAT™. The SD formability of POVACOAT™ was investigated by varying the...

[1] The Greenland ice sheet has been the focus of much attention recently because of increasing melt in response to regional climate warming and can be studied using Moderate Resolution Imaging Spectroradiometer (MODIS) and Quick Scatterometer (QuikSCAT) data. To improve our ability to measure surface melt, we use remote sensing data products to study surface and near-surface melt characteristi...