New tests of animal affect and welfare require validation in subjects experiencing putatively different states. Pharmacological manipulations of affective state are advantageous because they can be administered in a standardised fashion, and the duration of their action can be established and tailored to suit the length of a particular test. To this end, the current study aimed to evaluate a ph...

Triphalangeal thumb (TPT) is a rare congenital disorder characterised by a long, finger-like thumb with three phalanges instead of two. It can occur as an isolated defect, in association with other abnormalities of the hands and feet, or as a part of a syndrome. Sporadic cases have been described, but it is usually inherited as an autosomal dominant trait. In order to examine skeletal morpholog...

Stenemo, F., 2007. Vulnerability assessments of pesticide leaching to groundwater. Doctoral thesis. ISSN 1652-6880, ISBN 978-91-576-7356-5. Pesticides may have adverse environmental effects if they are transported to groundwater and surface waters. The vulnerability of water resources to contamination of pesticides must therefore be evaluated. Different stakeholders, with different objectives a...

In recent years, exterior thermal insulation systems became more and more important leading to an increasing amount of houses equipped with biocide-containing organic façade coatings or fungicide treated wood. It is known that these biocides, e.g. terbutryn, carbendazim, and diuron, as well as wood preservatives as propiconazole, leach out of the material through contact with wind driven rain. ...

Agonist-induced internalization of G protein-coupled receptors (GPCRs) is a well characterized phenomenon believed to contribute to receptor desensitization. The 5-hydroxytryptamine (5-HT)2C subtype of serotonin receptor is a GPCR that we have shown to internalize upon agonist incubation. In this study, we have examined the effects of 5-HT2C receptor agonists serotonin, Ro 60-0175 [(S)-2-(6-chl...

This paper presents a genetic algorithm (GA) approach to the problem of choosing C disjoint subsets of n items to be packed into distinct containers, such that the total value of the selected items is maximized, without exceeding the capacity of each of the containers. This so-called multiple container packing problem (MCPP) has applications in naval as well as financial management. It is a har...

BACKGROUND Evidence from both animal and human studies suggests that exposure to phthalates may be associated with adverse female reproductive outcomes. OBJECTIVE We evaluated the associations between urinary concentrations of phthalate metabolites and outcomes of assisted reproductive technologies (ART). METHODS This analysis included 256 women enrolled in the Environment and Reproductive ...

BACKGROUND The serotonin 5-HT2C receptor (5-HT2CR) is expressed in amygdala, a region involved in anxiety and fear responses and implicated in the pathogenesis of several psychiatric disorders such as acute anxiety and post traumatic stress disorder. In humans and in rodent models, there is evidence of both anxiogenic and anxiolytic actions of 5-HT2C ligands. In this study, we determined the re...

Phthalate exposure is prevalent in populations worldwide, including pregnant women. Maternal urinary metabolite concentrations have been associated with adverse reproductive outcomes, but underlying mechanisms remain unclear. Here we investigate inflammation as a possible pathway by examining phthalates in association with inflammation biomarkers, including C-reactive protein (CRP) and a panel ...