Technetium dichloride has been discovered. It was synthesized from the elements and characterized by several physical techniques, including single crystal X-ray diffraction. In the solid state, technetium dichloride exhibits a new structure type consisting of infinite chains of face sharing [Tc(2)Cl(8)] rectangular prisms that are packed in a commensurate supercell. The metal-metal separation i...

The rate of fatty acid synthesis in hepatocytes from meal-fed rats was manipulated over a wide range using glucose, lactate, and pyruvate to drive the system maximally, and glucagon, 5-(tetradecyloxy)-2-furoic acid (RMI 14,514), or a combination of both agents to inhibit lipogenesis. Measurements were made of cellular malonyl-CoA levels, long chain acylcarnitine concentration, and [l-‘4C]oleate...

After birth, a dramatic increase in fatty acid oxidation occurs in the heart, which has been attributed to an increase in l-carnitine levels and a switch from the liver (L) to muscle (M) isoform of carnitine palmitoyltransferase (CPT)-1. However, because M-CPT-1 is more sensitive to inhibition by malonyl CoA, a potent endogenous regulator of fatty acid oxidation, a switch to the M-CPT-1 isoform...

Anaerobic decarboxylation of malonate to acetate was studied with Sporomusa malonica, Klebsiella oxytoca, and Rhodobacter capsulatus. Whereas S. malonica could grow with malonate as sole substrate (Y = 2.0 g.mol-l) , malonate decarboxylation by K. oxytoca was coupled with anaerobic growth only in the presence of a cosubstrate, e.g. sucrose or yeast extract (Y, = 1.1-1.8 g.mol malonate-1). R. ca...

Muscle malonyl-CoA has been postulated to regulate fatty acid metabolism by inhibiting carnitine palmitoyltransferase 1. In nontrained rats, malonyl-CoA decreases in working muscle during exercise. Endurance training is known to increase a muscle's reliance on fatty acids as a substrate. This study was designed to investigate whether the decline in malonyl-CoA with exercise would be greater in ...

The asymmetric unit of the title compound, C(2)H(9)N(5) (2+)·2Cl(-), is composed of one diprotonated biguanidinium cation and two chloride anions. The diprotonated cation consists of two planar halves twisted by 36.42 (6)°. The ions are associated in the crystal structure by extensive hydrogen bonding into a three-dimensional network; the diprotonated biguanidinium cation is hydrogen bonded to ...

The title ionic compound, C(2)H(10)N(2) (2+)·2Cl(-), crystallizes with a center of symmetry within the cation. Each of the positively charged ammonium ends of the mol-ecule is trigonally hydrogen bonded to three different chloride counter-ions, while each of the chloride ions is trigonally hydrogen bonded to three different ethyl-enediammonium cations. The hydrogen-bonding network leads to stab...

The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin secretion (GIIS) predicts that malonyl-CoA derived from glucose metabolism inhibits fatty acid oxidation, thereby increasing the availability of LC-CoA for lipid signaling to cellular processes involved in exocytosis. For directly testing the model, INSr3 cell clones overexpressing malonyl-CoA decarboxylase in the cyt...

We have characterized two mutants of Escherichia coli in which fatty acid biosynthesis is adversely affected by elevated temperature. Under conditions which do not alter the activity of wild type cell-free extracts, virtually all of the malonyl coenzyme A-acyl carrier protein (ACP) transacylase and fatty acid synthetase activities present in mutant extracts are thermolabile. Malonyl transacylas...