Gender influences the incidence and severity of some bacterial and viral infections and autoimmune diseases in animal models and humans. To determine a gender-based difference, comparisons were made between male and female mice inoculated with herpes simplex virus type 1 (HSV-1) by the corneal route. Mortality was higher in the male mice of the three strains tested: 129/Sv//Ev wild type, gamma ...

Background: Therapeutic utilities of doxorubicin (DOX), an anticancer anthracycline antibiotic, are limited by its serious dosedependent toxicity to non-target tissues such as testis. The aim of the present study was to elucidate the potential of simvastatin (SIM), a lipid lowering agent with antioxidant and anti-inflammatory activities, to attenuate DOX-induced spermatotoxicity in male mice. M...

purpose: to evaluate the effects of silver nanoparticles on some serum parameters in mice. materials and methods: forty mice, including twenty male and twenty female, were randomly divided into eight groups: c1 and c2 (male and female control groups, respectively), t1, t2 and t3 (male treatment groups), t4, t5 and t6 (female treatment groups). after the acclimatization period, the treatment gro...

The purpose of the study was to assess transgenerational intestinal tumorigenic effects of low dose ionizing radiation employing a well-characterized mouse model of human colorectal cancer. Mice (6 to 8 weeks old APC1638N/+ mice; n=20 per study group) were exposed to whole-body 25 cGy x-rays and mated 2 days post-irradiation. Intestinal tumorigenesis in male and female F1 mice from No Parents I...

The purpose of the study was to assess transgenerational intestinal tumorigenic effects of low dose ionizing radiation employing a well-characterized mouse model of human colorectal cancer. Mice (6 to 8 weeks old APC1638N/+ mice; n=20 per study group) were exposed to whole-body 25 cGy x-rays and mated 2 days post-irradiation. Intestinal tumorigenesis in male and female F1 mice from No Parents I...

Objective(s): We examined the effects of endurance exercise in the presence of Bunium persicum extract administration on lipid profile and cardiorespiratory capacity in hypercholesterolemic male mice. Materials and Methods: Forty male hypercholesterolemic mice were divided into four groups: Vehicle, Endurance exercise (EE), Bunium persicum extract (BPE), and EE + BPE. The exercise protocol was ...