Abstract Background Cape Verde is an archipelago located off the West African coast and in a pre-elimination phase of malaria control. Since 2010, fewer than 20 Plasmodium falciparum cases have been reported annually, except 2017, when outbreak Praia before rainy season led to 423 autochthonous cases. It important understand genetic diversity circulating P. inform on drug resistance, potential ...

Thrombocytopenia frequently complicates malarial infections but the mechanism has not been elucidated. We studied 28 patients with malarial infections and noted that 16 of 17 thrombocytopenic patients had elevated levels of platelet-associated IgG (PAIgG). In all thrombocytopenic patients studied, the level of PAIgG returned to normal as the platelet count rose to normal levels. To study the me...

OBJECTIVES To draw attention to the extent of homozygous sickle cell (SS) disease as a public health problem in Uganda where a mean 20% frequency of the sickle cell trait implies that 25,000 babies with SS disease are born each year. To highlight the dangers of applying interventions developed in non-malarial areas to regions where malaria may change the natural history and outcome of sickle ce...

Anti-malarial drug resistance has been identified in many regions for a long time. In this paper we formulate a mathematical model of the spread of anti-malarial drug resistance in the population. The model is suitable for malarial situations in developing countries. We consider the sensitive and resistant strains of malaria. There are two basic reproduction ratios corresponding to the strains....

There is accumulating evidence for a role of immunoglobulin G (IgG) in protection against malarial infection and disease. Only IgG1 and IgG3 are considered cytophilic and protective against P. falciparum, whereas IgG2 and IgG4 were thought to be neither and even to block protective mechanisms. However, no clear pattern of association between isotypes and protection has so far emerged. We analyz...

Prompt and accurate diagnosis of malarial patients is a crucial factor in controlling the morbidity and mortality of the disease. Effective treatment decisions require a correct diagnosis among mixed-species malarial patients. Differential diagnosis is particularly important in cases of Plasmodium vivax, a species that shares endemicity with P. falciparum in most endemic areas. Moreover, it is ...

Sera from wild African black-footed penguins (Spheniscus demersus L., 1758), Adelie penguins (Pygoscelis adeliae Houbron, 1841), Gentoo penguins (Pygoscelis papua Forster, 1781), king penguins (Aptenodytes patagonicus Miller, 1778), and little blue penguins (Eudyptula minor Forster, 1781) and from captive yellow-eyed penguins (Megadyptes antipodes Houbron, 1841) and Magellanic penguins (Sphenis...

Immune responses to Plasmodium falciparum rhoptry-associated protein 1 (RAP-1), RAP-2, and RAP-3 appear to contribute to protection against infection by this human malarial parasite. This conclusion is suggested by results of monkey immunization trials and of cell culture studies showing antibody-dependent inhibition of erythrocyte invasion. In the present study, splenectomized owl monkeys were...