The chromosome 1p/19q deletion has been reported as a good prognosis marker for gliomas. However, the detection of 1p/19q status alone in glioma patients is not sufficient. The identification of a combination of molecular factors could effectively enhance the prediction accuracy. Thus far, the potential correlation between the 1p/19q status and vascular endothelial growth factor (VEGF) expressi...

Achieving total glioma resection represents a major challenge to neurosurgeons with no distinct margin between tumor and surrounding brain tissue. Many imaging methods are employed in surgery visualization and resection control. We performed this meta-analysis to assess the diagnosis value of intraoperative ultrasound and judged whether ultrasound is a suitable tool in detecting glioma residual...

Purpose: To evaluate both a histogram based analysis of MR-derived cerebral blood volume maps and metabolite ratios from proton MR spectroscopy in order to exploit the ability of each method to characterize gliomas and to evaluate their combined diagnostic potential. Background: The value of normalized cerebral blood volume ratio (nCBV) analysis to differentiate high-grade (WHO grade III-IV) fr...

Recent studies have demonstrated that microRNA-15b (miR-15b) regulates cell cycle progression, proliferationnd apoptosis in glioma cells by targeting Cyclins. However, the clinical significance of miR-15b in human glioma remains unclear. Therefore, the aim of this study was to investigate the significance of miR-15b expression in diagnosis, prognosis and malignant progression of glioma. Quantit...

BACKGROUND Polyploid giant cancer cells (PGCCs) contribute to solid tumor heterogeneity. This study investigated the relationships among PGCCs numbers, vasculogenic mimicry (VM) formation, and tumor grades in glioma. METHODS A total of 76 paraffin-embedded glioma tissue samples, including 28 cases of low grade and 48 cases of high grade gliomas, were performed with H&E and immunohistochemical...

Glioma is one of the most common primary brain tumors accounting for 30 to 40% of all intracranial tumors. Gliomas can be divided into two types based upon histopathalogic diagnosis according to the World Health Organization (WHO) classification, low grade (WHO I and II) and high grade (WHO III and IV). High grade malignant glioblastoma accounts for the majority of diagnoses and carries the wor...

Background: Gliomas are the most common primary neoplasms of the central nervous system. Relative cerebral blood volume (rCBV) could estimate high-grade Gliomas computed with dynamic susceptibility contrast MR imaging which it is artificially lowered by contrast extravasation through a disrupted blood-brain barrier. Objectives: Our intent was to clarify the usefulness of diffusion-weighted m...

Glioma, especially the high-grade glioma, is the most common primary brain malignant tumor, with extremely poor prognosis. Angiogenesis has been demonstrated to play a crucial role in the growth and metastasis of glioma. Fibulin-5 is a multifunctional extracellular matrix (ECM) protein that mediates cell-cell and cell-matrix communication. Recent evidence has suggested that Fibulin-5 is involve...

In previous studies we found expression of the protein colligin 2 (heat shock protein 47 (HSP47), SERPINH1) in glioma neovasculature while not in normal brain tissue. Generally, the regulation of heat shock gene expression in eukaryotes is mediated by heat shock factors (HSF). In mammals, three heat shock transcription factors, HSF-1, -2, and -4, have been isolated. Here we investigated the rel...