Modification of a metal surface by a strongly adsorbed chiral organic molecule has proven to be an interesting strategy for heterogeneous chiral catalysis. Platinum chirally modified by cinchona alkaloids, successfully applied for the enantioselective hydrogenation of alpha-ketoesters, is probably the most prominent catalyst based on this concept. Despite considerable research efforts toward un...

Disclosed herein is a stereoselective method for the synthesis of 2,3-furan fused carbocycles bearing adjacent quaternary and tertiary carbon stereocenters. The chemistry is based on an asymmetric addition of b-ketoesters to 2-(1-alkynyl)-2-alkene-1-ones catalysed by natural cinchona alkaloids followed by a silver-catalysed intramolecular cycloisomerisation. By exploiting the distinct catalysis...

A new synthesis of 3H-pyrimidin-4-ones, characterized by four different sets of decorations, is presented. The strategy is based on the synthetic elaboration of readily available α-substituted β-ketoesters that, upon transformation into the corresponding acyl enamines, have been cyclized to give 6H-1,3-oxazin-6-ones. These reactive intermediates have been in turn cleanly converted into highly f...

A convenient method is disclosed for the synthesis of both 3-hydroxyisoquinolines and 2-hydroxy-1,4-naphthoquinones from beta-ketoesters using a one-pot aryne acyl-alkylation/condensation procedure. When performed in conjunction with a one-step method for the synthesis of the beta-ketoester substrates, this method provides a new route to these polyaromatic structures in only two steps from comm...

in this work, so3h-functionalizedphthalimide (sfp) as a so3h-containing solid acid is prepared by the reaction of phthalimide with chlorosulfonic acid, and characterized by ft-ir, 1h and 13c nmr, mass, tg, dtg, xrd and sem. then, it is utilized as a highly efficient, heterogeneous and green catalyst for the one-pot multi-component condensation of dimedone with arylaldehydes, β-ketoesters and am...