Metformin hydrochloride is biguanide used as oral hypoglycemic agent. But its shows short biological half life (t1/2 3-4) which leads to high dosage frequency. Therefore, the present study aims to prepare the controlled release formulation of metformin hydrochloride loaded in the chitosan microspheres. It also involves the study of the effect drug to polymer ratio on the performance of chitosan...

The diverse community of microbes present in the human gut has emerged as an important factor for cancer risk, potentially by altering exposure to chemical carcinogens. In the present study, human gut bacteria were tested for their capacity to transform the carcinogenic heterocyclic amine 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx). Eubacterium hallii, Lactobacillus reuteri, and Lacto...

Dextromethorphan HBr is a synthetic antitussive compound. Biological half life of this drug is 2 to 4 hours. Due to its shorter half life the dose is upto 4 times a day, thereby reducing patient compliance. Thus to reduce the dose frequency and to improve the patient compliance sustained release tablets of freely water soluble Dextromethorphan HBr. was formulated with non-swellable waxy polymer...

A novel dual tablet formulation for oral administration using xanthan gum as the carrier and meloxicam as a model drug has been investigated for colonspecific drug delivery using invitro methods. The tablets were evaluated for hardness, thickness, drug content uniformity, and were subjected to invitro drug release studies under conditions mimicking mouth to colon transit and the results of whic...

Embryonic stem cells (ESCs) are established from the inner cell mass of a preimplantation embryo, are capable of self-renewal, and exhibit pluripotency. Given these unique properties, ESCs are expected to have therapeutic potential in regenerative medicine and as a powerful tool for invitro differentiation studies of stem cells. Various growth factors and extracellular matrix components regulat...

Embryonic stem cells (ESCs) are established from the inner cell mass of a preimplantation embryo, are capable of self-renewal, and exhibit pluripotency. Given these unique properties, ESCs are expected to have therapeutic potential in regenerative medicine and as a powerful tool for invitro differentiation studies of stem cells. Various growth factors and extracellular matrix components regulat...

Transfer RNAs isolated from Escherichia coli B grown in the presence of 2-thiouracil are deficient in pseudouridine. Much of this deficiency is from the T psi C region, which has only about 50% of its normal pseudouridine content. The other modified nucleoside from this region, ribothymidine, is reduced by only about 10%. Studies showed that 2-thiouracil is incoproated into the RNA of E. coli d...