نتایج جستجو برای: intestinal drug delivery

تعداد نتایج: 868479  

2017
Runcong Liu Ya-Nan Chang Gengmei Xing Min Li Yuliang Zhao

Drug nanocrystals (NCs) can improve the solubility and bioavailability of insoluble drugs for oral administration. However, the biocompatibility and mechanisms of transmittance of drug NCs through the intestinal epithelial tissue are still not well understood. In this work, the physico-chemical properties and interactions with biomolecules in oral delivery pathways, as well as the transmittance...

Journal: :Advanced drug delivery reviews 2013
Anne des Rieux Vincent Pourcelle Patrice D Cani Jacqueline Marchand-Brynaert Véronique Préat

Orally administered targeted nanoparticles have a large number of potential biomedical applications and display several putative advantages for oral drug delivery, such as the protection of fragile drugs or modification of drug pharmacokinetics. These advantages notwithstanding, oral drug delivery by nanoparticles remains challenging. The optimization of particle size and surface properties and...

2017
Rajan Rajabalaya Muhammad Nuh Musa Nurolaini Kifli Sheba R David

Liquid crystal (LC) dosage forms, particularly those using lipid-based lyotropic LCs (LLCs), have generated considerable interest as potential drug delivery systems. LCs have the physical properties of liquids but retain some of the structural characteristics of crystalline solids. They are compatible with hydrophobic and hydrophilic compounds of many different classes and can protect even biol...

2015
K. Raja Rao V. Vasu Naik A. Rajesh

Department of Pharmaceutics, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India. _______________________________________________________________________ ABSTRACT Conventional drug delivery systems have slight control over their drug release and almost no control over the effective concentration at the target site. This kind of dosing pattern may result in constantly changing, unpredictabl...

Journal: :international journal of nano dimension 0
n. dalili mansour young researchers and elite club, rasht branch, islamic azad university, rasht, iran f. mahboubi department of chemistry, rasht branch, islamic azad university, rasht, iran. n. nahrjou young researchers and elite club, rasht branch, islamic azad university, rasht, iran

having conducted fundamental projects, scientists have expressed their hope to develop the use of carbon nanotubes to release drugs. it is important to release drugs in cell without damaging healthy cells of tissues under study. researchers have shown the fact that nanotubes can perform this function perfectly. to this objective, in the present study the interactions between four anti-cancer dr...

Journal: :international journal of bio-inorganic hybrid nanomaterials 0

stabilities and quantum molecular descriptors of cyclophoshphamide (an anticancer drug)-functionalized (8,0) zigzag and (4,4) armchair carbon nanotubes (cnts) complexes in water were studied using density functional theory (dft) calculations. two attachments namely the sidewall- and tip-attachments are considered for the model constructions. calculations of the total electronic energy (et) and ...

2010
Yanhui Zhang Xinru Li Yanxia Zhou Xiaoning Wang Yating Fan Yanqing Huang Yan Liu

A series of monomethoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) diblock copolymers were designed according to polymer-drug compatibility and synthesized, and mPEG-PLA micelle was fabricated and used as a nanocarrier for solubilization and oral delivery of Cyclosporine A (CyA). CyA was efficiently encapsulated into the micelles with nanoscaled diameter ranged from 60 to 96 nm with a narro...

Journal: :Advanced pharmaceutical bulletin 2012
Badir Delf Loveymi Mitra Jelvehgari Parvin Zakeri-Milani Hadi Valizadeh

PURPOSE The purpose of this work was to preparation of vancomycin (VCM) biodegradable nanoparticles to improve the intestinal permeability, using water-in-oil-in-water (W/O/W) multiple emulsion method. METHODS The vancomycin-loaded nanoparticles were created using double-emulsion solvent evaporation method. Using Eudragit RS100 as a coating material. The prepared nanoparticles were identifyed...

ژورنال: پوست و زیبایی 2016
ایمان, مریم, رضوی, سیده‌‌حمیده, قاسمی, روح‌الله,

Transdermal drug delivery (TDD) is a non-invasive, topical administration method for therapeutic agents. Transdermal delivery also has advantages including providing release for long periods of time, improving patient compliance, and generally being inexpensive. Despite these advantages, the use of TDD has been limited by innate barrier functions of the skin. Only small (<500 Da), lipophilic mo...

Journal: :iranian journal of basic medical sciences 0
elham khodaverdi department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran pharmaceutical research center, avicenna institute, mashhad university of medical sciences, mashhad, iran omid rajabi department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran pharmaceutical research center, avicenna institute, mashhad university of medical sciences, mashhad, iran farshad farhadi department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran afshin jalali department of pharmaceutics, school of pharmacy, mashhad university of medical sciences, mashhad, iran

objective(s) physiological changes in the body may be utilized as potential triggers for controlled drug delivery. based on these mechanisms, stimulus-responsive drug delivery has been developed. materials and methods in this study, a kind of poly (n-isopropylacrylamide-acrylamide) membrane was prepared by radical copolymerization. changes in swelling ratios and diameters of the membrane were i...

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