نتایج جستجو برای: interleukin il 10 gene

تعداد نتایج: 2160116  

Journal: :novelty in biomedicine 0
ameneh koochaki biotechnology department, school of medicine, shahid beheshti university of medical sciences, tehran, iran mojgan bandehpour biotechnology department,school of medicine, shahid beheshti university of medical sciences and cellular and molecular research center, shahid beheshti university of medical sciences, tehran, iran and department of biotechnology, school of advanced technologies in medicine, shahid beheshti university of medical sciences, tehran, iran sam massahi cellular and molecular research center, school of medicine, shahid beheshti university of medical sciences, tehran, iran and department of nutrition and health sciences, university of nebraska-lincoln, lincoln, usa bahram kazemi biotechnology department, school of medicine, shahid beheshti university of medical sciences, tehran, iran

background: interleukin-27 is a heterodimeric cytokine belonging to il-12 and il-23 families, secreted  by antigen presenting cells( apcs ) .the il-27 is composed of 2 subunits: epstein-barr virus induced gene 3 (ebi3) and p28. il-27 is an anti-inflammatory cytokine which has an inhibitory effect on th17 population and suppress the il-17 expression. it is suggested that il-27 could be a potent ...

Dian Ratih Laksmitawati Maesaroh Maesaroh, Moordiani Moordiani, Ni Made Dwi Sandhiutami Nurul Fauziah, Wahyu Widowati,

Objective(s): Inflammation is an immune response toward injuries. Although inflammation is healing response, but in some condition it will lead to chronic disease such as rheumatoid arthritis, inflammatory bowel disease, atherosclerosis, Alzheimer’s and various cancer. Indonesian cassia (Cinnamomum burmanni C. Nees & T. Ness) known to contain coumarin, is widely used for alternative medicine es...

2014
Sweta Karan Himani Kaushik Nipun Saini Pramod K Sahoo Aparna Dixit Lalit C Garg

UNLABELLED Interleukin-10 (IL-10) is a pleiotropic cytokine and plays an important role in inflammation, immunoregulation and the pathogenesis of various diseases. Therefore, it is our interest to isolate, clone, sequence and characterize IL-10 gene from the fish Labeo rohita (Lr). The gene was amplified using genomic DNA isolated from head kidney with primers designed on conserved sequence hom...

2004
Frank Hoentjen R. Balfour Sartor Michitaka Ozaki Christian Jobin

Interleukin-10–deficient (IL-10 / ) mice develop an IL-12–mediated intestinal inflammation in the absence of endogenous IL-10. The molecular mechanisms of the dysregulated IL-12 responses in IL-10 / mice are poorly understood. In this study, we investigated the role of nuclear factor– B (NFB) and signal transducers and activators of transcription 3 (STAT3) in lipopolysaccharide (LPS)–induced IL...

Journal: :Gut 2000
G Barbara Z Xing C M Hogaboam J Gauldie S M Collins

BACKGROUND The development of colitis in interleukin 10 (IL-10) deficient mice, together with the known anti-inflammatory and immunomodulatory properties of this cytokine have prompted consideration of IL-10 as a treatment for inflammatory bowel disease (IBD). However, studies using hrIL-10 in IBD models have yielded inconsistent results. AIMS To examine the therapeutic potential of overexpre...

ژورنال: افق دانش 2021

Aims Physical inactivity is associated with low-grade systemic inflammation and thus increased risk of chronic disease. Beneficial effects of caffeine on adipocytes metabolism and its anti-inflammatory properties have been reported. The aim of this study was to evaluate the effect of 12 weeks combined training and caffeine on plasma levels of inflammatory and anti-inflammatory markers in obese ...

Journal: :Journal of Animal Science 2023

Abstract Previous studies have indicated the importance of Nod-like receptor pyrin containing domain 3 (NLRP3) to early immune response in St. Croix (STC) sheep. NLRP3 is important Th2 response, which classical Haemonchus contortus larval antigen (HcLA). driven by interleukin (IL) -4 and IL-13 cytokine production prevents parasite establishment further resistance as seen STC LPS, activation. Di...

Journal: :The Journal of Experimental Medicine 1998
Susan D. Spencer Francesco Di Marco Jeff Hooley Sharon Pitts-Meek Michele Bauer Anne M. Ryan Bernard Sordat Verna C. Gibbs Michel Aguet

The orphan receptor CRF2-4 is a member of the class II cytokine receptor family (CRF2), which includes the interferon receptors, the interleukin (IL) 10 receptor, and tissue factor. CRFB4, the gene encoding CRF2-4, is located within a gene cluster on human chromosome 21 that comprises three interferon receptor subunits. To elucidate the role of CRF2-4, we disrupted the CRFB4 gene in mice by mea...

2017
Hongmei Zhou Ailing Liu Bingzhi Zhou Cunxin Zhao Guangjun Jin

BACKGROUND The association between interleukin-10 (IL-10) gene rs1800896 polymorphism and susceptibility to acute pancreatitis (AP) has been investigated in several studies, but with contradictory findings. Therefore, a comprehensive meta-analysis is needed to assess the strength of such association. METHODS Literatures on PubMed, EMBASE, and CNKI were searched to identify relevant studies. T...

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