نتایج جستجو برای: insulin therapy
تعداد نتایج: 820216 فیلتر نتایج به سال:
Insulin detemir is a soluble long-acting human insulin analogue at neutral pH with a unique mechanism of action. Following subcutaneous injection, insulin detemir binds to albumin via fatty acid chain, thereby providing slow absorption and a prolonged metabolic effect. Insulin detemir has a less variable pharmacokinetic profile than insulin suspension isophane or insulin ultralente. The use of ...
OBJECTIVE A precise time-action profile of insulin lispro (Humalog) at mealtime may reduce the incidence of severe hypoglycemia. Because it is a rare complication, we performed a cumulative meta-analysis to compare the frequency of severe hypoglycemia during insulin lispro and human regular insulin therapy in type 1 diabetic patients. RESEARCH DESIGN AND METHODS The analysis included eight la...
INTRODUCTION Critically ill patients can develop hyperglycaemia even if they do not have diabetes. Intensive insulin therapy decreases morbidity and mortality rates in patients in a surgical intensive care unit (ICU) and decreases morbidity in patients in a medical ICU. The effect of this therapy on patients in a mixed medical/surgical ICU is unknown. Our goal was to assess whether the effect o...
Background: There is not any in vivo studies that shows inducing of euglycemia by vanadyl is independent from plasma insulin. Therefore in the present study we planned to investigate the antidiabetic effects of vanadyl in diabetic rats. Materials and Methods: Rats became severely diabetic by an IV injection of 50-55mg/kg streptozotocin (STZ), 15 days after the injection, the blood glucose of ...
BACKGROUND A recently halted clinical trial showed that intensive treatment of type 2 diabetes mellitus was associated with increased mortality. Given the phenotypic heterogeneity of diabetes, therapy targeted at insulin status may maximize benefits and minimize harm. METHODS In this longitudinal cohort study, we followed 503 patients with type 2 diabetes who were free of cardiovascular disea...
Insulin therapy remains the cornerstone of effective diabetes management. Timely intensification of insulin therapy reduces the progression of diabetes and the development of diabetes-related complications. Given that overall hyperglycaemia is a relative contribution of both fasting and postprandial hyperglycaemia, use of basal insulin alone may not achieve optimal glucose control due to its in...
BACKGROUND Hyperglycemia is associated with increased mortality in critically ill patients. Randomized trials of intensive insulin therapy have reported inconsistent effects on mortality and increased rates of severe hypoglycemia. We conducted a meta-analysis to update the totality of evidence regarding the influence of intensive insulin therapy compared with conventional insulin therapy on mor...
Introduction: Trinidad is a small island middle income country with a high prevalence of type 2 Diabetes. As much as 60% of patients are likely to need insulin therapy in the future. The first step in preparing a patient to convert to insulin therapy is to determine barriers to insulin therapy. The aim of this study is determine barriers to initiating insulin therapy in a primary care setting i...
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