The ADP-ribosyltransferase 3 gene (ART3) has been reported to be associated with non-obstructive azoospermia (NOA) in the Japanese population. In this study, we aim to explore the possible association between the four single nucleotide polymorphisms (SNPs) (rs11097230, rs17001385, rs14773 and rs6836703) in ART3 gene and male infertility with spermatogenesis impairment in the Chinese population....

Published data on the association between the GST genes polymorphisms and male infertility risk are inconclusive. We investigated GST genes polymorphisms in a large sample size case-control study, and conducted a literature-based meta-analysis of 6934 individuals. Our case-control study showed the GSTM1 null genotype was significantly associated with idiopathic oligozoospermia, while the null g...

A genetic basis of infertility may exist in many men currently classified as having idiopathic infertility. Approximately 7% of infertile men harbour submicroscopic deletions of the Y chromosome that are not detectable on routine karyotype. Two candidate gene families, namely the RNA-binding motif-containing gene family, and the deleted-in-azoospermia gene family, have been cloned by deletion m...

Mutations in the haemochromatosis gene (HFE) influence iron status in the general population of Northern Europe, and excess iron is associated with the impairment of spermatogenesis. The aim of this study is to investigate the association between three mutations (C282Y, H63D and S65C) in the HFE gene with idiopathic male infertility in the Chinese Han population. Two groups of Chinese men were ...

Small RNA has become a crucial regulator of protein synthesis during spermatogenesis. Alterations in small RNA function prove to be detrimental to proper spermatogenesis. As many patients suffer from idiopathic infertility, understanding the molecular mechanisms of small RNA identifies possible causes of certain types of infertility. With a comprehensive review of the history of miRNA and piRNA...

X-chromosome and its independent loci recently gained importance in genetic investigations concerned with disease control-case studies, population analyses, phylogenetic investigations. Infertility lack of normal reproduction are important issues health. Aazoospermia is a kind infertility men whose semen contains no sperm can affect about 1-20% the male population. The majority cases spermatoge...

The study examined the epidemiology and causes of infertility in Tomsk, Western Siberia, using methodological approaches recommended by WHO and was based on the findings for a randomly selected sample of 2000 married women aged 18-45 years. Among the respondents, 333 couples were considered infertile since they had not conceived after 12 months or more of unprotected intercourse. This group of ...

OBJECTIVE To illustrate the necessity for an enhanced understanding of the genetic basis of male factor infertility, to present a comprehensive synopsis of these genetic elements, and to review techniques being utilized to produce new insights in fertility research. BACKGROUND Male factor infertility is a complex disorder that affects a large sector of the population; however, many of its eti...

background: cytomegalovirus (cmv) is a prevalent infection in humans. recent studies have shown the role of cmv infection in male infertility disorder. aim: here we aimed to study the role of cmv infection in men with idiopathic infertility. materials and methods: we performed a case-control study of cmv serology in 200 patients attending male infertility clinic of a university hospital. there ...