background functional constipation (fc) and constipation-predominant irritable bowl syndrome (cibs)are two main subtypes of constipation that can be distinguished by the rome ii criteria. measuring colonic transit time (ctt) is an easy and cost effective way to evaluate constipation. this study was conducted to compare the ctt in patients with fc and cibs. materials and methods those patients w...

INTRODUCTION Although there are defined criteria for the diagnosis of constipation, in practice, diagnostic criteria are less rigid, and depend in part on the perception of normal bowel habit. Constipation is highly prevalent, with approximately 12 million general practitioner prescriptions for laxatives in England in 2001. METHODS AND OUTCOMES We conducted a systematic review and aimed to an...

Linaclotide, a synthetic guanylyl cyclase C (GC-C) agonist, and the prostone analog, Lubiprostone, are approved to manage chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. Lubiprostone also protects intestinal mucosal barrier function in ischemia. GC-C signaling regulates local fluid balance and other components of intestinal mucosal homeostasis including ep...

The colonic inertia is a cause of severe chronic constipation, causing slow intestinal transit in the whole extension of the large intestine. This disorder is still poorly understood, the pathophysiology has not been defined and there is disabled access to propaedeutics. It occurs more in women and is associated with improper diet, sedentary lifestyle, drugs, endocrine and metabolic alterations...