Effects of theophylline, lidocaine, cyclophosphamide, hyoscine N-butyl bromide, tranexamic acid and cytarabine on hexokinase (HK) from human erythrocytes have been investigated in vitro. In addition, in vivo effects of theophylline and lidocaine were investigated in rats. HK was purified from human red blood cells by DEAE-Sephadex A50 ion exchange chromatography. HK activity was measured spectr...

Papaveretum-hyoscine is a popular premedication for children but there is no agreement as to dosage. Four dosage schemes were compared in a double blind trial on children undergoing adenotonsillectomy in an attempt to determine the optimum method of using the drug mixture. No real difference in behaviour and co-operation in the anaesthetic room could be detected between any of the dosage scheme...

A novel recognition method for selective determination of the hyoscine N-Butyl bromide (HBB), an antispasmodic agent for smooth muscles, was devised using extended gate field-effect transistor (EG-FET) as transducing unit. For this purpose a PVC membrane, containing hyoscine n-butyl-tetraphenyl borate ion-pair as recognition component, was coated on Ag/AgCl wire, which was connected to the exte...

OBJECTIVES To develop a process of advance consent to enable research to be undertaken in patients in the terminal phase. DESIGN Feasibility study of an advance consent process to support a randomised controlled trial of two antimuscarinic drugs (hyoscine hydrobromide and glycopyrronium bromide) in the management of noisy respirations associated with retained secretions ("death rattle"). SE...

The management of 'death rattle' was reviewed by a task group on behalf of the Association for Palliative Medicine's Science Committee. Evidence was searched for the effectiveness of various anti-muscarinic drugs in drying oropharyngeal and bronchial secretions in dying patients. Clinical guidelines were constructed based on evidence from volunteer and clinical studies. Death rattle occurs in h...

RP-HPLC; Chromatography; Hyoscine N-butyl bromide and paracetamol Abstract RP-HPLC chromatographic method was developed for the determination of hyoscine N-butyl bromide (HBB) and Paracetamol (PAR). In this chromatographic method, HBB and PAR were separated using C18 (25 cm · 4.6 mm i.d. 5 lm particle size) column as a stationary phase and water: methanol (50:50, V/V pH adjusted to 3.9 with CF3...

Papaveretum 20 mg and morphine 10-20 mg, with and without the addition of hyoscine, were compared as pre-operative medication, studying also the operative and postopsrative sequelae. It is shown that the morphine content of papaveretum 20 mg is equivalent to 13.3 mg of morphine sulphate and this dose was included in the comparison. Papaveretum caused a higher incidence of pre-operative drowsine...