A fatty hydroxamic acid (FHA) mixture synthesized from olive oil triacylglycerides by 23 hydroxylaminolysis and composed predominantly of oleyl and linoleyl hydroxamic acid (OHA 24 and LHA, respectively) was characterized by means of IR, Raman, MS and 1D and 2D 1Hand 25 13C-NMR spectroscopy. The ratio of OHA and LHA (4:1) was confirmed by MALDI TOF/TOF 26 mass spectrometry. The radical scavengi...

cause the hydroxamic acid is readily reduced both in vivo and in vitro (9, 13, 16, 22), the balance of the N-hydroxyla tion and reduction reactions is of considerable importance in determining the carcinogenic dose applied to the tissues. Studies on the microsomal system which N-hydroxylates AAF have been reported by Irving (13) and are in progress in this laboratory (17). The present paper rep...

The synthesis and spectroscopic characterisation of novel mononuclear Ru(III)(edta)(hydroxamato) complexes of general formula [Ru(H2edta)(monoha)] (where monoha = 3- or 4-NH2, 2-, 3- or 4-C1 and 3-Me-phenylhydroxamato), as well as the first example of a Ru(III)-N-aryl aromatic hydroxamate, [Ru(H2edta)(N-Me-bha)].H2O (N-Me-bha = N-methylbenzohydroxamato) are reported. Three dinuclear Ru(III) com...

Members of the carotenoid cleavage dioxygenase family catalyze the oxidative cleavage of carotenoids at various chain positions, leading to the formation of a wide range of apocarotenoid signaling molecules. To explore the functions of this diverse enzyme family, we have used a chemical genetic approach to design selective inhibitors for different classes of carotenoid cleavage dioxygenase. A s...

Excess matrix degradation is one of the hallmarks of cancer and is an important factor in the process of tumor progression. It is implicated in invasion, metastasis, growth, angiogenesis and migration. Many characteristics of matrix metalloproteinases (MMPs) make them attractive therapeutic and diagnostic targets. MMP expression is upregulated at the tumor site, with localization of activity in...