نتایج جستجو برای: human osteoblast
تعداد نتایج: 1648510 فیلتر نتایج به سال:
Strontium-substituted hydroxyapatite (SrHAp) materials are known to actively promote bone formation. However, the optimum level of Sr inclusion needed elicit a physiologically relevant response from cells is unclear and can vary dependent on fabrication process employed. In this work (HAp), SrHAp powders (2, 5 10 wt% (i.e., 1, 2 at%) with respect [Sr/(Sr + Ca) ?100]), were synthesized purity Sr...
Abbreviations: A0: Cross-Section; BDNF: Brain Derived Growth Factor; BMP: Bone Morphogenetic Proteins: CGF: Concentrated Growth Factors: EGM: Endothelial Growth Medium:EBM-2: Endothelial Basal Medium 2; F: Load; FGM: Fibroblast Growth Medium; FBM: Fibroblast Basal Medium; H: Height; H0: Initial Height; HE: Hematoxylin And Eosin Staining; HOB: Human Osteoblasts; HRP: Horseradish Peroxidase; HUVE...
The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteoblast differentiation belonging to the runt family of tumor suppressor genes, is consistently disrupted in osteosarcoma cell lines. Ectopic expression of runx2 induces p27KIP1, thereby inhibiting the activity of S-phase cyclin complexes and lea...
In vitro studies evaluating the cytotoxic potential of substances released from dental adhesives are lacking. The purpose this study was to compare cytotoxicity extracts Scotchbond Universal and Optibond Solo Plus, an adhesive in experimental phase: T1. 3T3 mouse fibroblast cells MG-63 osteoblast-like human osteosarcoma were exposed for 24 h serial extract dilutions. Cytotoxicity determined usi...
Objective(s): Design and construction of biocompatible and biodegradable scaffolds are among the main goals of tissue engineering. Recently, use of nano-hydroxyapatite as a bioactive bioceramic agent with high similarity to the mineral phase of the human bone tissue, in combination with biodegradable polymers and implant coatings has attracted the attention of researchers in the field of biomat...
The monoamine serotonin (5-hydroxytryptamine, 5-HT), a well-known neurotransmitter, also has important functions outside the central nervous system. The objective of this study was to investigate the role of 5-HT in the proliferation, differentiation, and function of osteoblasts in vitro. We treated rat primary calvarial osteoblasts with various concentrations of 5-HT (1 nM to 10 µM) and assess...
Bone is a dynamic tissue that is continuously being remodeled throughout life. Specialized cells called osteoclasts transiently break down old bone (resorption process) at multiple sites as other cells known as osteoblasts are replacing it with new tissue (bone formation). Usually, both resorption and formation processes are in balance and thereby maintain skeletal strength and integrity. This ...
Periprosthetic osteolysis is a major cause of aseptic loosening in artificial joint replacement. It is assumed to occur in conjunction with the activation of macrophages. We have shown in vitro that human osteoblast-like cells, isolated from bone specimens obtained from patients undergoing hip replacement, phagocytose fine particles of titanium alloy (TiAlV). The human osteoblast-like cells wer...
introduction: iiron oxide nanoparticles (io np) have an increasing number of biomedical applications. to date, the potential cytotoxicity of these particles remains an issue of debate. little is known about the cellular interaction or toxic effects of io np on differentiation of stem cells. the aim of the present study was to investigate the possible toxic role of different doses of io np in di...
We investigated the effects of human granulocyte macrophage-colony stimulating factor (GM-CSF) on the relation between differentiation and apoptosis in SaOS-2 cells, an osteoblast-like cell line. To determine the relationship between these cellular processes, SaOS-2 cells were treated in vitro for 1, 7 and 14 days with 200 ng/mL GM-CSF and compared with untreated cells. Five nM insulin-like gro...
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