OBJECTIVE To test the association between cognitive impairment, with and without subcortical features, and insulin resistance in an elderly community-dwelling population. DESIGN Cross-sectional wave of an epidemiologic longitudinal study (InCHIANTI). PARTICIPANTS A total of 523 people, aged 70 to 90 years without diabetes mellitus or hyperglycemia, from the InCHIANTI cohort were included in...

BACKGROUND Previous epidemiological investigations of associations between dietary glycemic intake and insulin resistance have used average daily measures of glycemic index (GI) and glycemic load (GL). We explored multiple and novel measures of dietary glycemic intake to determine which was most predictive of an association with insulin resistance. METHODS Usual dietary intakes were assessed ...

OBJECTIVE Low levels of physical activity appear to be associated with insulin resistance. However, the detailed associations of these complex relationships remain elusive. We examined the prospective associations between self-reported TV viewing time, objectively measured time spent sedentary, at light-intensity activity, and at moderate- and vigorous-intensity physical activity (MVPA) with in...

Background and aims: We sought to examine the interaction between CRY1 genotypes low carbohydrate diet (LCD) score effect on insulin resistance, sensitivity, homeostasis model assessment of resistance (HOMA- IR) quantitative sensitivity check index (ISQUKI). Methods: This cross-sectional study was conducted with a total 228 overweight obese women. The data related anthropometric biochemical mea...

Background. To assess fasting C-peptide and insulin indices using homeostatic model assessment (HOMA) in gestational diabetes mellitus (GDM). Methods. Gestational (n = 64, age: 27.02 ± 0.53 years, BMI: 26.3 0.5 kg/m2; mean SEM) normal glucose tolerance NGT 56, 26.11 0.55 24.4 0.4 screened according to WHO 2013 criteria. Glucose was measured by oxidase method whereas ELISA. HOMA-IR, HOMA-B HOMA-...

Insulin resistance is common among children with overweight and obesity. However, knowledge about glucose fluctuations in these children is scarce. This study aims to evaluate glycaemic profiles in children with overweight and obesity in free-living conditions, and to examine the association between glycaemic profiles with insulin resistance and cardiovascular risk parameters. One hundred eleve...

OBJECTIVE To evaluate whether treatment of mild gestational diabetes mellitus (GDM) confers sustained offspring health benefits, including a lower frequency of obesity. RESEARCH DESIGN AND METHODS Follow-up study of children (ages 5-10) of women enrolled in a multicenter trial of treatment versus no treatment of mild GDM. Height, weight, blood pressure, waist circumference, fasting glucose, f...

BACKGROUND Fatness and fitness both influence cardiometabolic risk. OBJECTIVE The purpose of this study was to investigate whether childhood fatness and increasing fatness from childhood to adolescence are associated with cardiometabolic risk during adolescence and how fitness affects this association. SUBJECTS AND METHODS Of 565 adolescents (283 boys and 282 girls) from the TRacking Adoles...

PURPOSE Insulin resistance (IR) has an important role in the development of non-alcoholic steatohepatitis (NASH). We aimed to analyze the association between liver histopathology and IR in pediatric patients with NASH. MATERIALS AND METHODS In 24 children with non-alcoholic fatty liver disease (NAFLD), we investigated whether the hepatic pathologic characteristics have relations with followin...

AIM The aim of this study was to investigate the relationship between four circulating adipocytokines (apelin, vaspin, visfatin, adiponectin) and markers of insulin sensitivity, in the context of polycystic ovary syndrome (PCOS) in adolescents. SUBJECTS AND METHODS 48, obese, adolescent girls (mean age: 15.6±3.4 years, mean body mass index standard deviation score (BMI-SDS): 2.31±0.1), and 37...