The United States Food and Drug Administration (FDA) uses alfuzosin as an example of a drug having QT risk in humans that was not detected in nonclinical studies. FDA approval required a thorough clinical QT study (TCQS) that was weakly positive at high doses. The FDA has used the clinical/nonclinical discordance as a basis for mandatory TCQS, and this requirement has serious consequences for d...

Abstract Human non-mercaptalbumin (HNA), oxidized form of serum albumin, has been reported as a useful marker in oxidative stress-related diseases; however, few reports have examined the association between HNA and severity coronary artery disease (CAD). The present study evaluated whether fraction is correlated with stenosis 140 patients considered to high risk CAD or who were suspected having...

BACKGROUND Improving the quality of health care services requires tailoring facilities to fulfil patients' needs. Satisfying patients' healthcare needs, listening to patients' opinions and building a closer provider-user partnership are central to the NHS. Few published studies have discussed cardiovascular patients' health needs, but they are not comprehensive and fail to explore the contribut...

PURPOSE An earlier study showed that 4-hydroxynonenal (HNE), formed as a result of increased lipid peroxidation in oxidative stress, causes loss of lens transparency. To determine how HNE is detoxified in ocular tissues, its metabolism in cultured human lens epithelial cells (HLECs) as well as rat lens was investigated. METHODS Rat lens or HLECs were incubated with 30 nmol (5 x 10(5) cpm/ mic...

Individuals with spinal cord injuries above thoracic level 6 (T(6)) experience episodic bouts of life-threatening hypertension as part of a condition termed autonomic dysreflexia. The paroxysmal hypertension can be caused by a painful stimulus below the level of the injury. Targeted ablation of mesenteric projecting sympathetic neurons may reduce the severity of autonomic dysreflexia by reducin...

The laryngotracheal cartilage is a cardinal framework for the maintenance of airway breathing, which occasionally requires reconstruction. Because hyaline has poor intrinsic regenerative ability, various approaches have been attempted to regenerate cartilage. use autologous mesenchymal stem cells (MSCs) regeneration widely investigated. However, long-term culture may limit proliferative capacit...

Sudden changes in drinking water quality can cause harmful consequences for end users. Thus, real-time monitoring of allow early warning and provide crucial gains securing safe distribution. This study investigated the advantages simultaneous measuring flow cytometry fluorescence spectroscopy. A contamination event was a laboratory-scale analysis by spiking samples with organic nutrients. Flow ...