Accepted 29 March 1996 In 1953, Lichtenstein introduced the unifying term 'histiocytosis X' to embrace several previous eponyms, including eosinophilic granuloma, Letterer-Siwe disease and Hand-Schuller-Christian disease.' In 1987, a more prominent designation, Langerhans cell histiocytosis (LCH), was recommended to replace histiocytosis X.' The term is more appropriate as it reflects the fact ...

The cellular mechanisms involved in the development of silicosis have not been fully elucidated. This study aimed to examine influence of silica-induced lung injury on autophagy. Suspensions of crystalline silica particles were administered transnasally to C57BL/6j mice. Immunohistochemical examination for Fas and p62 protein expression was performed using lung tissue specimens. Two-dimensional...

Pulmonary histiocytosis X is the local manifestation of a systemic disorder of unknown cause characterised by infiltration of Langerhans cell like histiocytes and parenchymal fibrosis. In a male smoker with histologically proved histiocytosis X and functional impairment bronchoalveolar lavage showed an increase in CD-1/OKT-6 antigen positive histiocytes to 8%. Northern blot analysis of RNA from...

Angiotensin converting enzyme: a tumour marker in malignant histiocytosis Angiotensin converting enzyme is present in vascular endothelial cells and in cells of the monocyte macrophage series. Serum activities of the enzyme may be raised in active sarcoidosis, Gaucher's disease, leprosy, asbestosis, and silicosis,' in hyperthyroidism,2 and in alcoholic liver disease and diabetes mellitus with s...

Rosai-Dorfman disease (RDD) is a rare benign proliferative disorder of histiocytes in the lymph nodes with or without extranodal involvement. RDD limited to the skin without nodal involvement, known as cutaneous Rosai-Dorfman disease, is very rare. We describe a 34-year-old female with RDD of the skin over the chest. A large nodule with satellite lesions was excised for histopathological examin...

Infiltration of the lamina propria of the mucosa of the small intestine with 'foamy' macrophages (histiocytes) which give a strongly positive cytoplasmic reaction with the periodic acid-Schiff (P.A.S.) stain is considered diagnostic of Whipple's disease (Black-Schaffer, 1949; Chears, Hargrove, Verner, Smith, and Ruffin, 1961; Farnan, 1958; Plummer, Russi, Harris, and Caravati, 1950; Sieracki an...

Few studies have been conducted to evaluate the cellular composition of the granulomatous lesions induced by Lacazia loboi. Thus, the objective of the present study was to characterize the mononuclear cell population present in cutaneous lesions obtained from 15 patients with Jorge Lobo's disease. Histological sections were stained with hematoxylin-eosin and methenamine silver and the following...

We made an ultrastructural study of the site of a transplanted syngeneic hepatocarcinoma and its draining lymph nodes in inbred guinea pigs, in the presence and absence of Mycobacterium bovis strain Bacillus Calmette-Guérin.The bacillus was injected into the growing intradermal tumor 7 days after transplantation, at which time it had metastasized to the first regional lymph node. Critical morp...