Consumption of herbal leafy porridges is a reputed dietary remedy among Sri Lankans in treating diabetes. The aim of the study was to develop a rice based herbal porridge [rice: fresh leaves: scraped coconut kernel 13 15: 25 30: 10 13 (w/w/w)] commercially with Scoparia dulcis leaves which has proven antidiabetic effects and low GI (fresh porridge) which benefits diabetics. Two porridges with t...

Tephorsia purpurea Linn. (Fabaceae), commonly known as Saraphunkha, is an important indigenous medicinal plant used for centuries in Indian System of Medicine (ISM). It is an important ingredient of several marketed herbal formulations like Tephroli and Yakrifit used for liver disorders. Various plant parts have been used as remedy for impotency, asthma, diarrhoea, gonorrhoea, rheumatism, and u...

We have studied the effects of various Kampo medicines on P-glycoprotein (P-gp), a drug transporter, in vitro. The present study focused on Daiokanzoto (Da-Huang-Gan-Cao-Tang), which shows the most potent inhibitory effects on P-gp among the 50 Kampo medicines studied, and investigated the P-gp inhibitory effects of Daiokanzoto herbal ingredients (rhubarb and licorice root) and their components...

Dietary supplement-induced adverse effects often resolve quickly after discontinuation of the offending product, especially in younger patients. The potential for unwanted outcomes can be amplified in elderly patients or those taking multiple prescription drugs, especially where interactions exist with drugs metabolized by cytochrome P450 enzymes. Attributing injury or illness to a specific sup...

Medicinal plants have been considered valuable and cheap source of unique phytoconstituents which are used extensively in the development of drugs against various diseases. A large proportion of the world population, especially in the developing countries relies mainly on the traditional system of medicine. The use of plants and plant products in medicines is getting popularized because the her...

We investigated the effects of herbal extracts, a mixture of Scutellariae Radix and Platycodi Radix containing the active ingredients Baicalin and Saponin (target herbal ingredient (THI)), on lowering body weight. The present study was a prospective, randomized, double-blind, and placebo-controlled trial carried out at the outpatient department of a hospital over a period of 2 months. Group 1 p...

An extract of the plant Coleus forskohlii has been used for centuries in Ayurvedic medicine to treat various diseases such as hypothyroidism, heart disease, and respiratory disorders. Additionally, complex herbal mixtures containing this extract are gaining popularity in United States for their putative "fat-burning" properties. The active ingredient in C. forskohlii extract is the diterpene co...

ESP-102, an extract from Angelica gigas, Saururus chinensis, and Schisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivities in vitro and in vivo studies, its effects on neuronal networks remain elusive. To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array...

Guggulsterone is the active ingredient in gugulipid, an organic extract of the Commiphora mukul plant. Gugulipid has been used for nearly 3000 years in Ayurvedic medicine, mainly as a treatment for arthritis. Herbal practitioners currently use gugulipid therapy in conditions as diverse as rheumatism, coronary artery disease, arthritis, hyperlipidemia, acne, and obesity. The active ingredient in...

Indirubin is the crucial ingredient of Danggui Longhui Wan and Qing-Dai, traditional Chinese medicine herbal formulas used for therapy chronic myelocytic leukemia in China hundreds years. Although monomeric indirubin has been treatment human leukemia. However, due to low water solubility, poor pharmacokinetic properties therapeutic effects are major obstacle, had significantly limited its clini...