A simple protocol for iron-catalyzed cross-coupling of nonactivated secondary alkyl bromides and iodides with alkynyl Grignard reagents at room temperature has been developed. A wide range of secondary alkyl halides and terminal alkynes are tolerated to afford the substituted alkynes in good yields. A slight modification of the reaction protocol also allows for cross-coupling with a variety of ...

Presented herein is a mild, facile, and efficient iron-catalyzed synthesis of substituted allenes from propargyl carboxylates and Grignard reagents. Only 1-5 mol % of the inexpensive and environmentally benign [Fe(acac)3 ] at -20 °C was sufficient to afford a broad range of substituted allenes in excellent yields. The method tolerates a variety of functional groups.

In this work, we describe the one-pot synthesis of α-amino nitrile units by concomitant addition alkyl (or aryl) Grignard reagents and TMS cyanide through alkylative Strecker cyanation from readily available formamides. The reaction is broad in scope conditions are mild, inexpensive, easy to set-up, providing numerous nitriles good yields (34 examples, 41–94 % yield).

P,N,N-Pincer nickel complexes [Ni(Cl){N(2-R2PC6H4)(2'-Me2NC6H4)}] (R = Ph, 3a; R = Pr(i), 3b; R = Cy, 3c) were synthesized and their catalysis toward the Kumada or Negishi cross-coupling reaction of aryl fluorides and chlorides was evaluated. Complex 3a effectively catalyzes the cross-coupling of (hetero)aryl fluorides with aryl Grignard reagents at room temperature. Complex 3a also catalyzes t...

............................................................................................ 27 Introduction ........................................................................................ 27 Results and Discussion ..................................................................... 31 Synthesis of a Functionalized Lactide Monomer ......................... 31 Copolymerization of L-Lac...

This Review describes the recent progress and new methodologies in organic synthesis based on use of various lanthanide metals as efficient reducing agents, radical generators or precursors Grignard reagents. It was shown that other than widely employed ytterbium samarium metal can have a beneficial impact certain transformations, for example C?F bond activation combination with early transitio...