Bin-Amphiphysin-Rvs (BAR) domain proteins are central regulators of many cellular processes involving membrane dynamics. BAR domains sculpt phosphoinositide-rich membranes to generate membrane protrusions or invaginations. Here, we report that, in addition to regulating membrane geometry, BAR domains can generate extremely stable lipid microdomains by "freezing" phosphoinositide dynamics. This ...

N. E. Adam, J. P. Alexander, C. Bebek, B. E. Berger, K. Berkelman, F. Blanc, V. Boisvert, D. G. Cassel, P. S. Drell, J. E. Duboscq, K. M. Ecklund, R. Ehrlich, L. Gibbons, B. Gittelman, S. W. Gray, D. L. Hartill, B. K. Heltsley, L. Hsu, C. D. Jones, J. Kandaswamy, D. L. Kreinick, A. Magerkurth, H. Mahlke-Kruger, T. O. Meyer, N. B. Mistry, E. Nordberg, M. Palmer, J. R. Patterson, D. Peterson, J. ...