نتایج جستجو برای: glucose intolerance
تعداد نتایج: 193260 فیلتر نتایج به سال:
Etiology of type 2 diabetes in older adults The incidence of type 2 diabetes in older adults is attributable to two primary factors: 1) changes in metabolism (e.g., increased insulin resistance and decreased insulin production) and 2) changes in weight and physical activity. The development of glucose intolerance is a recognizable metabolic change that occurs during aging, and some degree of gl...
Etiology of type 2 diabetes in older adults The incidence of type 2 diabetes in older adults is attributable to two primary factors: 1) changes in metabolism (e.g., increased insulin resistance and decreased insulin production) and 2) changes in weight and physical activity. The development of glucose intolerance is a recognizable metabolic change that occurs during aging, and some degree of gl...
Background: Early detection of carbohydrate intolerance is important to prevent maternal and perinatal complications. This study aims to determine association of symptoms and clinical feature with different degree of carbohydrate intolerance in comparison with healthy pregnant women. Methods: Two thousand four hundred sixteen pregnant women referred to five university hospital clinics were f...
BACKGROUND Macrophage and lymphocyte infiltration in adipose tissue may contribute to the pathogenesis of obesity-mediated metabolic disorders. Natural killer T (NKT) cells, which integrate proinflammatory cytokines, have been demonstrated in the atherosclerotic lesions and in visceral adipose tissue. OBJECTIVE To determine whether NKT cells are involved in glucose intolerance and adipose tis...
Background and Objective: Post-transplant diabetes mellitus (PTDM) is one of the problems occurring after kidney transplantation. This study was designed to detect the probable relationship between the glucose intolerance and serum and urinary concentrations of β2-microglobulin as well as their value to predict acute rejection of the transplant. Materials and Methods: In this cohort study, 40 p...
Endothelium-derived nitric oxide (NO) facilitates skeletal muscle glucose uptake. Energy expenditure induces the endothelial NO synthase (eNOS) gene, providing a mechanism for insulin-independent glucose disposal. The object was to test 1) the association of genetic variation in eNOS, as assessed by haplotype-tagging single nucleotide polymorphisms (htSNPs) with type 2 diabetes, and 2) the inte...
The prevalence of insulin resistance and type 2 diabetes increases rapidly; however, treatments are limited. Various herbal extracts have been reported to reduce blood glucose in animals with either genetic or dietary type 2 diabetes; however, plant extracts are extremely complex, and leading compounds remain largely unknown. Here we show that 5-O-methyl-myo-inositol (also called sequoyitol), a...
It is well established that subjects with liver cirrhosis are insulin resistant, but the contribution of defects in insulin secretion and/or action to glucose intolerance remains unresolved. Healthy individuals and subjects with liver cirrhosis were studied on two occasions: 1) an oral glucose tolerance test was performed, and 2) insulin secretion was inhibited and glucose was infused in a patt...
Obesity-related insulin resistance represents the core component of the metabolic syndrome, promoting glucose intolerance, pancreatic beta cell failure and type 2 diabetes. Efficient and safe insulin sensitization and glucose control remain critical therapeutic aims to prevent diabetic late complications Here, we identify transforming growth factor beta-like stimulated clone (TSC) 22 D4 as a mo...
Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes mellitus was described as an early pathogenetic phenomenon[1]. Moreover, impaired action of insulin (insulin resistance) has been associated with pre-diabetic state, impaired glucose tolerance and diabetes mellitus[2]. It is postulated that IR then leads to insulin deficiency. Thus, glucose into...
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