We kindly thank Dr. Khalangot for his comments (1). The literature contains conflicting results regarding whether an increased overall mortality (or cardiovascular mortality) risk accompanies the various sulfonylureas (2–5). The reason for this discrepancy is likely multifactorial as these reports differ in terms of their design and study populations, as well as their choice of variables for wh...

Respiratory Syncytial Viral Infection is one of the most common viral infections in respiratory airways and more infants, younger children some adults. Although ribavirin has been used management RSV infection, many effective drugs are still under development. Also, structured based drug design using computational tools shifted paradigm discovery. The fusion core (RSV) structure crucial for its...

the purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose k 100 (hpmck) and eudragit l 100. the granules were prepared by wet granulation method and thereby formulated as f-1, f-2. f-3 and...

Numerous oral antidiabetic drugs with different mechanisms of action have been developed to lower glucose and delay the occurrence of serious complications in patients with type 2diabetes [1]. For glycemic control in diabetic patients, monotherapy with an oral antidiabetic agent is not adequate to achieve satisfactory blood glucose control [2]. Thus, combination regimens which include drugs wit...

The purpose of this study was formulation and in vitro evaluation of floating-bioadhesive tablets to lengthen the stay of glipizide in its absorption area. Effervescent tablets were made using chitosan (CH), hydroxypropyl methylcellulose (HPMC), carbopolP934 (CP), polymethacrylic acid (PMA), citric acid, and sodium bicarbonate. Tablets with 5% effervescent base had longer lag time than 10%. The...

• Demographics: 66 year old African American male • Chief complaint: Hazy vision in the morning upon wakening OU, relief with warm compresses • Past ocular history: o Diabetic without retinopathy OD, OS o Non-visually significant cataracts OD, OS o Vitreoretinal Traction OD o History of spark from M16 rifle hitting the left eye during military service, treated and patched. Resolved. • Past medi...

THE CASE: An 84-year-old man with a history of stable angina, type 2 diabetes, hyperlipidemia, and hypertension presents to the emergency department with worsening dyspnea and peripheral edema. Congestive heart failure is diagnosed, and the patient is admitted to the care of a hospitalist. A standard therapeutic regimen, including diuretics, angiotensin-converting enzyme inhibitors, and oxygen,...