Genome sequencing is a very important tool for the development of genetic diagnosis, drugs of gene engineering, pharmacogenetics, etc. As the HGP comes into people’s ears, there is an emerging need for the genome sequencing. During the recent years, there are two different traditional strategies available for this target: shotgun sequencing and hierarchical sequencing. Besides these, many effor...

background: weissellicin 110 is the only bacteriocin reported in weissella cibaria up to now. this bacteriocin represents several unique features. this is the first report on the gene sequence that encodes for the bacteriocin.objectives: providing a rapid detection method to isolate the weissellicin 110 encoding gene and determination of the bacteriocin distribution were the objectives.material...

Completion of tomato genome sequencing project has broad impacts on genetic and genomic studies of tomato and Solanaceae plants. The reference genome sequence derived from Solanum lycopersicum cv 'Heinz 1706' serves as the firm basis for sequencing-based approaches to tomato genomics. In this article, we first present a brief summary of the genome sequencing project and a summary of the referen...

Introduction Twenty years ago, the Human Genome Project made history by announcing sequencing of 92% human genome through development modern genetic techniques. In 2022, complete DNA was announced. This knowledge it possible to better understand how genetics influences functioning body and, at same time, facilitated identification variants that can cause diseases. field cardiology, study assist...

This study emphasizes the importance of aligning short reads in analysis human whole-genome sequencing data. The alignment process involves determining positions genetic sequences relative to a known reference genome sequence genome. Traditional methods use linear sequence, but this can lead incorrect alignment, especially when contain variations. In work, index file was modified using minimap2...

There is increasing evidence that several genes are associated with an increased risk of type 2 diabetes (T2D); genome-wide association investigations and whole-genome re‑sequencing investigations offer a useful approach for the identification of genes involved in common human diseases. To further investigate which polymorphisms confer susceptibility to T2D, the present study screened for high‑...

Next-generation sequencing technologies have greatly lowered the cost of whole-genome sequencing (WGS) and related approaches. Thus, comprehensive sequencing for diagnostic purposes may clear this financial hurdle in the near future. The report by Bainbridge and colleagues in this issue of Science Translational Medicine illustrates the diagnostic power of WGS. In this Perspective, we discuss wh...

DNA sequencing has been revolutionized by the development of high-throughput sequencing technologies. Plummeting costs and the massive throughput capacities of second and third generation sequencing platforms have transformed many fields of biological research. Concurrently, new data processing pipelines made rapid de novo genome assemblies possible. However, high quality data are critically im...