background: gastric outlet obstruction (goo) due to peptic stricture is one of three known complications of peptic ulcer disease and usually requires therapeutic intervention for symptoms relief. after benjamin sb who primarily used balloon dilation for treatment of goo in 1982, some series has been published investigating procedure efficacy with different results. the purpose of this study is ...

This study examines the relationship between Helicobacter pylori infection and peptic ulcer disease and gastric cancer--in particular, the presence or absence of bacteria, the grading of gastritis, and the degree of inflammation in the antral and oxyntic mucosae. The grading of gastritis and the detection of H pylori were determined by histology using the Sydney system. Of the 1006 patients exa...

AIM To compare the effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing. METHODS Male Spraque-Dawley rats (n=48) were divided into four groups. Group1 served as control group, group 2 as gastric ulcer group without treatment, groups 3 and 4 as gastric ulcer treatment groups with sucralfate and Aloe vera. The rats from each group we...

Zinc has been reported to exert a gastroprotective action against various experimental gastric lesions suggesting that this trace element is involved in the integrity of the gastric mucosa. Compounds containing zinc, such as polaprezinc, were developed in Japan and used as an antiulcer drugs in the treatment of human peptic ulcer disease. However, the precise mechanism of Zn(2+) containing comp...

  It has been revealed that dopamine (DA) modulates gastro-duodenal responses to stress. Several investigations have been made to identify the mechanisms and/or receptors by which DA or its promoters exert their gastroprotective function against stress, however there are many discrepancies in this respect. In order to clarify the relative contribution and/or interaction of two DA receptor subty...

Objective: Nelumbo nucifera Gaertn. (Nymphaeceae) is a well known aquatic herb which has been extensively used traditionally for the treatment of different diseases. Therefore present study was designed to evaluate the anti-ulcer activity of methanolic extract of Nelumbo nucifera Gaertn. (Nymphaeceae) stalks. Methods: Anti-ulcer activity of methanolic extract of Nelumbo nucifera (100 mg/kg and ...

A Peptic ulcer is a mucosal lesion of the stomach or duodenum in which the acid and pepsin play major pathogenic roles. The major forms of peptic ulcer are gastric ulcer and duodenal ulcer, both of which are chronic diseases often caused by Helicobacter pylori. The term peptic ulcer also encompasses gastric ulcers and duodenal ulcers associated with stress or the ingestion of drugs, most common...

conclusions tg showed protective effect against ethanol induced gastric ulcer. this study confirmed traditional medicine claims of tg. objectives the aim of the present study was to determine the acute toxicity and protective effect of hydroalcoholic extract of tg (hetg) against ethanol induced gastric ulcer. materials and methods male wistar rats were divided into five groups (n = 7). hetg at ...

BACKGROUND Nonsteroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. This paper reviews th...

BACKGROUND The study was carried out to determine the cytotoxic, antioxidant and gastro-protective effect of ethyl-4-[(3,5-di-tert-butyl-2-hydroxybenzylid ene)amino] benzoate (ETHAB) in rats. METHODOLOGY/PRINCIPAL FINDINGS The cytotoxic effect of ETHAB was assessed using a MTT cleavage assay on a WRL68 cell line, while its antioxidant activity was evaluated in vitro. In the anti-ulcer study, ...