Herein, we report a simple and convenient procedure to prepare para-disubstituted [2.2]paracyclophanes in straightforward manner. Our approach relies on regioselective formylation of N-substituted 4-amino[2.2]paracyclophanes, which allows an easy access series products incorporating reactive aldehyde function para the electron-donating group. These compounds can be engaged variety orthogonal la...

Heterogeneously catalyzed N-formylation of amines to formamide with CO2/H2 is highly attractive for the valorization CO2. However, relationship catalytic performance catalyst structure still elusive. Herein, mixed valence catalysts containing Cu2O/Cu interface sites were constructed this transformation. Both aliphatic primary and secondary diverse structures efficiently converted into desired f...

In most organisms 10-formyl-tetrahydrofolate (10-CHO-THF) participates in the synthesis of purines in the cytosol and formylation of mitochondrial initiator methionyl-tRNA(Met). Here we studied 10-CHO-THF biosynthesis in the protozoan parasite Leishmania major, a purine auxotroph. Two distinct synthetic enzymes are known, a bifunctional methylene-tetrahydrofolate dehydrogenase/cyclohydrolase (D...

Pseudoephedrine is widely employed as a chiral auxiliary in diastereoselective alkylation reactions and provides ready access to enantiomerically enriched carboxylic acids, aldehydes, ketones, and alcohols. Because pseudoephedrine can be transformed into methamphetamine and other illegal drug substances, many countries restrict or ban its sale and distribution, thus complicating its use in indu...

Global drive away from fossil feedstock requires the development of synthetic procedures to enhance efficiency CO2 capture and utilization processes using renewable starting materials catalysts. Here, we report an alternative reaction pathway for O-formylation alcohols bio-alcohols, which affords industrially relevant formate esters. Most products, reported herein, derive their carbon atoms exc...

Cellulose was modified by formic acid to prepare formyl cellulose (FC). The amount of groups in FC adjusted controlling the reaction time, temperature, and concentration. Then, used reinforce polylactic (PLA) films prepared solution casting. Scanning electron microscopy (SEM) shows that long rod-like particles were broken into short rods after formylation introduction made PLA surface rougher. ...