Abstract This paper presents a parameter free approach to identify the importance of reactions (and involved species) in biochemical reaction networks for purpose model order reduction. The new methodology is based on structure network assuming that at steady state flux distribution preserved. Our method employs Flux Balance Analysis (FBA) calculate these distributions. ranking comparison FBA r...

In recent years, there have been considerable advances in the use of genome-scale metabolic models to provide accurate phenotype simulation methods, which in turn enabled the development of efficient strain optimization algorithms for Metabolic Engineering. In this work, we address some of the limitations of previous studies regarding strain optimization algorithms, mainly its use of Flux Balan...

Several researchers have argued that the functional behavior assessment (FBA) and behavior intervention plan (BIP) mandates in the Individuals With Disabilities Education Act of 2004 have gone beyond the current research base. For instance, although BIPs have been shown to improve student outcomes when implemented with strict control and oversight by researchers, it is unclear whether these rel...

Flux balance analysis (FBA) determines theoretical capabilities of metabolic networks using only stoichiometry and fundamental physiochemical capacity constraints. Metabolic networks reconstructed from annotated genome and literature. Capacity constraints include maximum uptake rates of oxygen and substrates such as glucose, acetate, and lactose. FBA determines optimal flux distribution for giv...

Function Block Adapters (FBAs) are new modeling elements, responsible for the connection of UML capsules and function blocks of the IEC 61131-3 standard. FBAs contain an interface to capsules as well as to function blocks and a description of the mapping between these interfaces. In this paper we discuss implementation issues of FBAs. While the specification of FBAs is completely platform-indep...