Exposure to nanoparticles during pregnancy is a public concern, because nanoparticles may pass from the mother to the fetus across the placenta. The purpose of this study was to determine the possible translocation pathway of gold nanoparticles across the maternal-fetal barrier as well as the toxicity of intravenously administered gold nanoparticles to the placenta and fetus. Pregnant ICR mice ...

the placental adhesive disorders such as placenta accreta and placenta percreta are the rare causes of serious obstetric hemorrhages. they are associated with high maternal morbidity and mortality. placenta percreta is usually diagnosed in the third trimester of pregnancy as a massive postpartum hemorrhage when an attempt to remove the placenta reveals lack of a cleavage plane. here we report a...

Ontogeny of fetal hepatic and placental growth and in vitro oxygen consumption (VO2) was investigated in fetal lambs at 75, 100, and 136 days postconception. Fetal hepatic relative weight and placental absolute and relative weights declined during this period. Oxygen consumption per gram dry weight of fetal liver and maternal placenta declined between mid and late gestation while fetal placenta...

Maternal lipids are strong determinants of fetal fat mass. Here we review the overall lipid metabolism in normal and gestational diabetes mellitus (GDM) pregnancies. During early pregnancy, the increase in maternal fat depots is facilitated by insulin, followed by increased adipose tissue breakdown and subsequent hypertriglyceridemia, mainly as a result of insulin resistance (IR) and estrogen e...

s: Background: In fluorosis endemic area, the amount of fluoride transferred to the fetus is significant in determining the early onset of fluorosis. The role played by placenta in transporting fluoride and other ions which are present in high concentrations in the local drinking water is studied. Aims & Objectives: The aim of the present study is to decipher the role of placenta in transport o...

The placenta, which presents unceremoniously after delivery of the neonate, has been given the undignified name afterbirth. This often ignored structure is, in fact, a critical organ that should not be an afterthought in the study of obstetric anesthesia. Revered by ancient cultures as the seat of the external soul or the bundle of life, the placenta has been the subject of many cultural ritual...

Intrauterine growth of fetus mainly depends on adequate function of placenta. Placenta is a fetal organ. It shares same stress and strain to which the fetus is exposed. Thus any disease which affects the mother has a great impact on placenta. Anatomical structure of placenta greatly influences its function. Thus study of placental morphology is considered essential. 136 Pregnancy complications ...

OBJECTIVES To investigate if there is subspecies specific migration to the placenta by Fusobacterium nucleatum (Fn) and to determine whether experimentally induced periodontitis results in adverse pregnancy outcomes (APO) in mice. METHODS Periodontitis was induced in pregnant mice using an inoculum of Fn and Porphyromonas gingivalis. In parallel, four sub-species of Fn were individually injec...

We determined recent trends and recurrence rates of placenta praevia in 790,366 deliveries in NSW. From 2001 to 2009, the rate of placenta praevia increased by 26%, from 0. 69% to 0. 87% (trend P < 0.001). The placenta praevia recurrence rate in a second birth was 4.8%. Two-thirds of the increase in placenta praevia was accounted for by trends in known risk factors, and the unexplained portion ...

Perinatal nitrosamine exposures may contribute to childhood cancer risk. To test primate fetal susceptibility to formation of cancer initiation-related DNA adducts from nitrosamines, pregnant patas monkeys were given 1.0 or 0.1 mg/kg N-nitrosodimethylamine. Appreciable levels of the promutagenic O6-methylguanine adduct occurred in placental and fetal liver DNA after both doses and were lower bu...