Aim . To study the features of clinical manifestations pneumonia that developed in children with COVID-19. Materials and methods The data case histories 36 aged from 8 months to 17 years, who were hospitalized children’s infectious diseases department Mytishchi City Clinical Hospital, analyzed for confirmed release SARS-CoV-2 virus. On first day hospitalization, all underwent examination: exami...

Results We analyzed 132 patients (85F/47M; mean age of 63.98 ±17.68 years) with maculopapular exanthema (MPE) (21.2%), DRESS (28.0%), overlap MP/DR (25.8%), Stevens-Johnson syndrome/toxic epidermal necrolysis (12.1%), acute generalized exanthematous pustulosis (8.3%), fixed drug eruption (3.78%) and urticaria/angioedema (0.76%), caused mainly by allopurinol (36.5%), antimicrobials (30.8%) and a...

BACKGROUND Baboon syndrome is a distinctive skin reaction in which the patient typically develops erythematous buttocks that appear similar to those of a baboon. The non-contact allergenic variant of baboon syndrome is also referred to as symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). Zoledronic acid is a bisphosphonate that is used in patients with metastatic cancer t...

The term "baboon syndrome" (BS) (recently known as symmetrical drug related intertriginous and flexural exanthema, SDRIFE) was introduced in 1984 to describe a specific skin eruption (resembling the red gluteal area of baboons) that occurred after systemic exposure to contact allergens. The crucial characteristics include a sharply defined symmetric erythema in the gluteal area and in the flexu...

Adverse drug reactions with an immunological basis (ADRIB) may involve activation of other concomitant, non-specific mechanisms, amplifying the specific response and contributing to the severity and duration. One concomitant mechanism could be the generation of reactive oxygen species (ROS) and/or their detoxification by anti-oxidants, including anti-oxidant enzymes. We analysed the activity of...