نتایج جستجو برای: epicatechin

تعداد نتایج: 3939  

Journal: :Molekul: Jurnal Ilmiah Kimia 2021

Chisocheton balansae C.DC., is one of the Meliaceae family plants which endemic from Soputan Mountain, North Sulawesi, Indonesia. This study was aimed to determine chemical structure flavan-3-ol compounds ethyl acetate extract C. C.DC stembark. Dried powder stem bark extracted consecutively with n-hexane, acetate, and methanol solvents. Four compounds, named catechin (1), epicatechin (2), epiga...

2018
Yihui Gong Fang Fang Xin Zhang Bin Liu Honghui Luo Zhen Li Xuelian Zhang Zhaoqi Zhang Xuequn Pang

Litchi (Litchi chinensis Sonn.) fruit is known for its rich source of phenolics. Litchi pericarp contains high levels of epicatechin that may form oligomers of various lengths. Except for several A or B type epicatechin dimers, other soluble oligomers have rarely been identified in the pericarp. Here, bioassay-guided column fractionation was applied to isolate bioactive phenolics from aqueous p...

Journal: :The British journal of nutrition 2010
A Spadafranca C Martinez Conesa S Sirini G Testolin

Dark chocolate (DC) may be cardioprotective by antioxidant properties of flavonoids. We investigated the effect of DC (860 mg polyphenols, of which 58 mg epicatechin) compared with white chocolate (WC; 5 mg polyphenols, undetectable epicatechin) on plasma epicatechin levels, mononuclear blood cells (MNBC) DNA damage and plasma total antioxidant activity (TAA). Twenty healthy subjects followed a...

Journal: :Biological & pharmaceutical bulletin 2015
Akiko Takagaki Fumio Nanjo

Bioconversion of (-)-epicatechin (-EC), (+)-epicatechin (+EC), (-)-catechin (-C), and (+)-catechin (+C) by (-)-epigallocatechin (-EGC)-metabolizing bacteria, Adlercreutzia equolifaciens MT4s-5, Eggerthella lenta JCM 9979, and Flavonifractor plautii MT42, was investigated. A. equolifaciens MT4s-5 could catalyze C ring cleavage to form (2S)-1-(3,4-dihydroxyphenyl)-3-(2,4,6-trihydroxyphenyl)propan...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2010
Ariadna Selga María Pilar Vinardell Raquel Martín-Venegas Olga Jáuregui Josefina Casas Josep Lluís Torres

The epicatechin (EC) thio derivatives 4β-(S-cysteinyl)-epicatechin (Cys-EC) and 4β-(S-cysteaminyl)-epicatechin (Cya-EC) are compounds that may provide protection from oxidation via mechanisms involving either the flavonoid moiety or the nonphenolic cysteine or cysteamine part of the molecule. Because the metabolically modified molecules may be the actual active species, we estimated the absorpt...

2013
Yongzhen Pang I. Sarath B. Abeysinghe Ji He Xianzhi He David Huhman K. Mudith Mewan Lloyd W. Sumner Jianfei Yun

Tea (Camellia sinensis) is rich in specialized metabolites, especially polyphenolic proanthocyanidins (PAs) and their precursors. To better understand the PA pathway in tea, we generated a complementary DNA library from leaf tissue of the blister blightresistant tea cultivar TRI2043 and functionally characterized key enzymes responsible for the biosynthesis of PA precursors. Structural genes en...

2013
Matheus Balduíno Goncalves dos Reis Letícia Correa Manjolin Claudia do Carmo Maquiaveli Osvaldo Andrade Santos-Filho Edson Roberto da Silva

Epigallocatechin-3-gallate (EGCG), a dietary polyphenol (flavanol) from green tea, possesses leishmanicidal and antitrypanosomal activity. Mitochondrial damage was observed in Leishmania treated with EGCG, and it contributed to the lethal effect. However, the molecular target has not been defined. In this study, EGCG, (+)-catechin and (-)-epicatechin were tested against recombinant arginase fro...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Jun Wang Mario G Ferruzzi Lap Ho Jack Blount Elsa M Janle Bing Gong Yong Pan G A Nagana Gowda Daniel Raftery Isabel Arrieta-Cruz Vaishali Sharma Bruce Cooper Jessica Lobo James E Simon Chungfen Zhang Alice Cheng Xianjuan Qian Kenjiro Ono David B Teplow Constantine Pavlides Richard A Dixon Giulio M Pasinetti

While polyphenolic compounds have many health benefits, the potential development of polyphenols for the prevention/treatment of neurological disorders is largely hindered by their complexity as well as by limited knowledge regarding their bioavailability, metabolism, and bioactivity, especially in the brain. We recently demonstrated that dietary supplementation with a specific grape-derived po...

Journal: :Bulletin of the Agricultural Chemical Society of Japan 1960

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