3-Hydroxypy rid ine-2-carboxaldehyf le thiosemicarbazone (3-HP) has been shown to be active against leukemia L1210, Ehrlich ascites carcinoma, lym]>homa L5178Y, the Lewis lung carcinoma, and adenocarcinoma 755. 3-HP is active, in some in stances, by gavage and also by delayed treatment. 3-HP is a member of a broad class of a-(.Y)-heterocyclic carboxaldehyde thiosemicarbazones, several of which ...

phenyl phenanthridinium bromide) has been shown to inhibit completely the incorporation of preformed purines into the nucleic acids of Ehrlich ascites carcinoma cells, but the drug does not ap preciably inhibit the incorporation of radioactive glycine into nucleic acids or proteins (4). These studies have been interpreted in terms of disrup tion of the normal relationship between intracellu lar...

It is becoming obvious that all cancers have a defective p53 pathway, either through TP53 mutation or deregulation of the tumor suppressor function of the wild type TP53. In this study we examined the expression of P53 and Caspase 3 in transperitoneally injected Ehrlich Ascites carcinoma cells (EAC) treated with Tetrodotoxin in the liver of adult mice in order to evaluate the possible pro apopt...