The present work aims to characterize and quantify the phenolic composition and to evaluate the antioxidant activity of Glycyrrhiza glabra L. (commonly known as licorice) rhizomes and roots. The antioxidant potential of its methanol/water extract could be related to flavones (mainly apigenin derivatives), flavanones (mainly liquiritin derivatives), a methylated isoflavone and a chalcone, identi...

Thirteen isolates of Cladobotryum spp., isolated from diseased fruiting bodies of Agaricus bisporus, sampled from mushroom farms in Serbia during 2003-2006, were studied. Sensitivity to several selected fungicides was tested and all isolates were found to be highly sensitive to iprodione (EC50 = 0.35-2.30 mg L-1), benomyl (EC50 = 0.14-0.97 mg L-1) and especially to prochloraz-Mn (EC50 = 0.02-0....

A novel series of diethyl {4-[(5-substituted-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates designed as analogues of amonafide was synthesized. All phosphonates were assessed for antiviral activity against a broad range of DNA and RNA viruses and several of them showed potency against varicella-zoster virus (VZV) [EC50 (50% effective concentration) =...

The anaerobic mixed microbiote may be inhibited through different mechanisms: inhibition by product or substrate, by the physical characteristics of the medium (pH or temperature), and by inhibitory substances, organic or inorganic. Biological activity tests have been the most widely used, of different experimental procedures known, to evaluate the toxicity of various compounds in anaerobic pro...

Pentacyclic triterpenoic acids, betulinic acid, platanic oleanolic acid and ursolic were acetylated subsequently converted into mono-, bis- tris(hydroxyl)ethyl amides. While parent compounds are of none or minor cytotoxicity, these amides showed EC50 values even in low μM concentration for a variety different human tumor cell lines. Especially bis(hydroxyethyl)amide 12 derived from held an = 7....

Background: White button mushroom (Agaricus bisporus) is a sensitive agricultural crop whose antioxidant properties are decreased during postharvest storage. In this study, the effect of citric acid dipping treatment on bioactive components and antioxidant properties of sliced button mushroom (Agaricus bisporus) was investigated. Methods: Fresh mushrooms soaked in chilled citric acid soluti...

El cultivo del plátano (Musa spp.) se ve afectado por diversas enfermedades que disminuyen el rendimiento y calidad. La Sigatoka negra (Pseudocercospora fijiensis) es principal problema fitopatológico en este cultivo, lo estudió la sensibilidad de P. fijiensis a cinco fungicidas sistémicos (Tebuconazol, Bitertanol, Pirimetanil, Trifloxistrobin Tridemorf) tres Unidades Producción Plátano (UPP). ...

A series of novel pyrimidinylthioacetanilides were designed, synthesized, and evaluated for their biological activity as potent HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Most of the tested compounds were proved to be effective in inhibiting HIV-1 (IIIB) replication with EC50 ranging from 0.15 μM to 24.2 μM, thereinto compound 15 was the most active lead with favorable inhi...