1 . Rats and mice were kept in a decompression chamber at 52 kPa (390 mmHg) for 1-4 weeks and their hearts and lungs were compared with littermate control animals. In both species growth was retarded in the hypoxic environment. 2. In both species small peripheral lung vessels became thickened, developing two elastic laminae with a muscular coat between. A method was developed for assessing thes...

A posteromedian muscle ridge is found in the left ventricle between the two atrioventricular valves in congenital malformations of the heart, where malalignment exists between the ventricular septum and the junction ofboth atrioventricular valve rings; this is seen in transposition with straddling tricuspid valve and double inlet ventricle with outflow chamber. In hearts with normal alignment o...

A rare case of an infant with "double inlet right ventricle" (straddling mitral valve) and double outlet right ventricle is described. Coarctation of the aorta was associated. A left-to-right shun*t resulted from part of the mitral valve opening into the right ventricle and also from the presence of a ventricular septal defect. The infant's clinical features reflected the shunt, although the va...

A 50-year-old woman with a history of mild exertional dyspnea for several years was consulted for preoperative cardiovascular evaluation as a result of an abnormal ECG. Physical examination revealed a blood pressure of 154/90 mm Hg and a regular pulse rate of 84 beats per minute. Cardiac auscultation noted a grade 2/6 systolic murmur at the apex and the lower left sternal border. No peripheral ...

Adequate growth of the hypoplastic right ventricle in a patient with severe pulmonary stenosis with an intact ventricular septum was documented after pulmonary valvotomy in infancy. It is postulated that the growth of the ventricular chamber is largely the result of pulmonary regurgitation resulting from successful pulmonary valvotomy. Based on this and the observations of others on the growth ...