BACKGROUND Patients suffering from cutaneous leishmaniasis (CL) caused by New World Leishmania (Viannia) species are at high risk of developing mucosal (ML) or disseminated cutaneous leishmaniasis (DCL). After the formation of a primary skin lesion at the site of the bite by a Leishmania-infected sand fly, the infection can disseminate to form secondary lesions. This metastatic phenotype causes...

Visceral leishmaniasis (VL) or kala-azar, a disseminated infection of the lymphoreticular system of the body, is marked by severe defect in immune system of the host. Successful cure of VL depends on the immune status of the host in combination with the effects of the antileishmanial drugs. The rationale approach towards eradication of this disease would be to potentiate the immune functioning ...

Leishmaniasis transmitted by sandflies is an important vector-borne disease. In Chad, information on outdated, and so this study was designed to update the sandfly fauna. Sandflies were collected in five health districts representing two geoclimatic zones using sticky traps pyrethrum sprays indoor peridomestic habitats between September 2019 December 2020. All specimens identified based species...

Background Leishmaniasis is an infectious disease caused by intracellular parasite of the genus Leishmania. According to clinical expression, it can be identified: subclinical, cutaneous (CL) and visceral leishmaniasis (VL). The immune response triggered in this type infections based activation TH1 pathway, which molecules such as TNF α interleukins IL 12 IL1 are involved [1,2]. In recent years...

BACKGROUND Nitric oxide (NO*) plays a pivotal role as a leishmanicidal agent in mouse macrophages. NO* resistant Escherichia coli and Mycobacterium tuberculosis have been associated with a severe outcome of these diseases. METHODS In this study we evaluated the in vitro toxicity of nitric oxide for the promastigote stages of Leishmania (Viannia) braziliensis and Leishmania (Leishmania) amazon...

Leishmaniasis is a zoonotic parasitic disease that affects both humans and animals. Canines are considered the main reservoirs of disease, while cats can present as secondary reservoirs, altering epidemiological cycle disease. The work describes first case feline foot hyperkeratosis in Asunción-Paraguay associated with leishmaniasis, determined by cytological diagnosis, favorable response to tr...

Neglected tropical diseases (NTDs) comprise of a group 17th infectious conditions endemic in many developing countries. Among these diseases, deadly, prevalent parasitic infection such as leishmaniasis, presents significant global burden which is responsible for high morbidity/mortality rate especially low-and middle-income/developed countries transmitted by phlebotomines sandflies. As per the ...

Leishmaniasis is a wide-spectrum disease caused by parasites from Leishmania genus. A well-modulated immune response that established after the long-lasting clinical cure of leishmaniasis can represent standard requirement for vaccine. Previous studies demonstrated (Viannia) naiffi causes benign and its antigens induce responses in vitro. In this work we aimed to identify immunodominant protein...

Cutaneous Leishmaniasis (CL) is a vector borne disease caused by various species of the Leishmania parasite. CL is endemic in the province of Balochistan in Pakistan. In certain instances a Human Immunodeficiency Virus (HIV)-related immunocompromised is associated with atypical clinical presentation and occurrence of reactivated lesions of CL. Such presentations respond poorly to the standard t...