Diabetes mellitus is a well-recognized risk-factor for coronary artery disease. It is known that diabetic patients have a two-to fourfold increased risk of mortality or morbidity for cardiovascular diseases compared with the general population. Further, many diabetic patients with coronary heart disease have severe diseased coronary arteries: multi-vessel disease and/or severe stenosed vessel(s...

Background: The major effects of regular exercise on diabetes mellitus are glycemic status improvement and amelioration of cardiovascular dysfunctions. This research examines whether moderate-intensity aerobic exercise can change the gene expression of metalloproteinase-2 and angiostatin in diabetic rats' heart tissue. Materials & Methods: In this experimental study, thirty Wistar rats were ca...

Kato, Kiminori, Donald C. Chapman, Heinz Rupp, Anton Lukas, and Naranjan S. Dhalla. Alterations of heart function and Na1-K1-ATPase activity by etomoxir in diabetic rats. J. Appl. Physiol. 86(3): 812–818, 1999.— To examine the role of changes in myocardial metabolism in cardiac dysfunction in diabetes mellitus, rats were injected with streptozotocin (65 mg/kg body wt) to induce diabetes and wer...

Ischemic heart disease (IHD) and diabetes mellitus (DM) are leading causes of death worldwide. Cardiac energy metabolism is profoundly altered in both of these conditions, which can lead to permanent cardiac pathologies that include heart failure and diabetic cardiomyopathy. Diabetic hearts show an increased dependence on oxidation of fatty acids for the production of adenosine triphosphate (AT...

Insulin-like growth factor (IGFs: IGF-I and IGF-II) systems have been reported to be associated with the onset of diabetic mellitus. Therefore, we investigated the effect of diabetes on regulation of the IGF system in the liver, kidneys and heart, which are important organs in the pathogenesis of diabetes. The experimental groups were subdivided into three groups: 1) controls, 2) streptozotocin...

Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the underlying molecular mechanisms for diabetic cardiomyopathy/heart failure are poorly understood. Insulin2 mutant (Ins2+/-) Akita is a mouse model of T1DM, which manifests cardiac dysfunction. However, molecular changes at cardiac transcriptome level that lead to cardiomyopathy remain unclear. To understand ...