do not persist for more than three weeks.4 Likewise, there was no evidence of haemosiderin deposition in the stalk which might be expected after haemorrhage. Stalk enlargement could have been an effect of untreated diabetes insipidus, in which the first case might have expected resolution of the abnormality with treatment. However, the swelling persisted for three months despite adequate treatm...

BACKGROUND Tubulointerstitial nephritis and uveitis syndrome (TINU syndrome) is a diagnosis of exclusion based on the presence of uveitis and acute tubulointerstitial nephritis in the absence of other disease entities known to cause both of these disorders. The proximal tubule is frequently affected by this syndrome, resulting in a wide range of presentations that vary from proteinuria to full ...

Rathke's Cleft Cyst (RCC), which is located at the intrasellar region, is considered to be the distended remnants of Rathke's pouch, an invagination of the stomodeum. Lined with columnar or cuboidal epithelium of ectodermal origin, RCC usually contains mucoid material and it is found in 13-22% of normal pituitary glands. The cyst rarely leads to the development of symptoms but, when it does, th...

Aldosterone-producing adrenal adenoma can induce various clinical manifestations as a result of chronic exposure to aldosterone. We report a rare case of a 37-year-old man who complained of general weakness and polyuria. He was diagnosed with aldosterone-producing adrenal adenoma and nephrogenic diabetes insipidus. Aldosterone enhances the secretion of potassium in the collecting duct, which ca...

MILLER, M. & MOSES, A.M. (1969) Chlorpropamide induced release of antidiuretic hormone in patients with diabetes insipidus (abstracts). Clinical Research, 17, 290. MILLER, M. & MOSES, A.M. (1970a) Potentiation of vasopressin action by chlorpropamide in vivo. Endocrinology, 86, 1024. MILLER, M. & MOSES, A.M. (1970b) Mechanism of chlorpropamide in diabetes insipidus. Journal of Clinical Endocrino...

This patient has cranial diabetes insipidus and hypoparathyroidism with low serum testosterone level and normal range FSH and LH. There was no evidence of granulomatous diseases, histiocytosis or sarcoidosis despite a history ofpolyuria for more than 10 years, although these may take years to manifest2 and diabetes insipidus may be an early manifestation. However, as has been reported,' about 3...