Long-acting depot antipsychotics were developed specifically to promote treatment adherence (compliance) and they are a valuable option for patients requiring maintenance medication for schizophrenia. Depot use has fallen in recent years, perhaps owing to the introduction of oral atypical antipsychotics. Psychiatrist and patient acceptance of depot medication is variable. The depot formulation ...

long protocol of gonadotropin-releasing hormone-analougue (gnrh-a) can result in the formation of ovarian cyst by the transient initial stimulatory effect which increases the levels of both follicle-stimulating hormone (fsh) and luteinizing hormone (lh). these cysts require surgical drainage or result in poor ovarian response. ovarian cyst formation can be prevented by taking oral contraceptive...

Establishing innovative fulfillment options for online orders has become a key challenge bricks-and-mortar retailers. A mere focus on store sales is no longer affordable due to the competition by pure players. Retailers are continuously developing new approaches order and last-mile logistics. Further shortening lead times becoming even more important in this context. One recently developed conc...

Wepropose a generalization of themulti-depot capacitated vehicle routing problemwhere the assumption of visiting each customer does not hold. In this problem, called the Multi-Depot Covering Tour Vehicle Routing Problem (MDCTVRP), the demand of each customer could be satisfied in two different ways: either by visiting the customer along the tour or by “covering” it. When a customer is visited, ...

The Two-Echelon Vehicle Routing Problem (2E-VRP) is an extension of the classical VRP where the delivery from a single depot to customers is managed by routing and consolidating the freight through intermediate depots called satellites. We presented several meta-heuristics based on separating the first and second level routing problems and solving iteratively the two resulting routing subproble...

Abstract This paper introduces the Hierarchical Multi-Switch Multi-Echelon Vehicle Routing Problem, a new variant of well-known Problem. It is real-world problem originating from policies Nordic distribution company. The includes single depot, non-predetermined hierarchy intermediate facilities, and two different fleets, consisting homogeneous original local vehicles, which are pulling swap-bod...

In Multi-Echelon Vehicle Routing Problems the delivery from one or more depots to the customers is managed by routing and consolidating the freight through intermediate depots, called satellites. This family of problems differs from Multi-Echelon Distribution Systems present in the literature. In the latter the attention is focused on the flow assignment among the levels only, while we also con...

An agent-based approach is used to explain the formation of vortex swarms in biological systems. The dynamics of the multiagent system is described by 3N coupled equations, modeling for each agent its position, its velocity and its internal energy depot. The energy depot considers the conditions for active biological motion, such as energy take-up, metabolism, and energy conversion. The equatio...

The Multi-Depot Vehicle Routing Problem (MDVRP) is a generalization of the Single-Depot Vehicle Routing Problem (SDVRP) in which vehicle(s) start from multiple depots and return to their depots of origin at the end of their assigned tours. The traditional objective in MDVRP is to minimize the sum of all tour lengths, and existing literature handles this problem with a variety of assumptions and...