نتایج جستجو برای: cytochrome p450 monooxygenase
تعداد نتایج: 62812 فیلتر نتایج به سال:
The polymorphic human cytochrome P450 (P450) 2B6 is primarily responsible for the metabolism of several clinically relevant drugs including bupropion, cyclophosphamide, propofol, and efavirenz. Although a number of single nucleotide polymorphisms have been found in the P450 2B6 gene, the influence of these variants on the metabolism of substrates and on the response to known inactivators of P45...
The steroid 20-hydroxyecdysone (20E) is the primary regulatory hormone that mediates developmental transitions in insects and other arthropods. 20E is produced from ecdysone (E) by the action of a P450 monooxygenase that hydroxylates E at carbon 20. The gene coding for this key enzyme of ecdysteroidogenesis has not been identified definitively in any insect. We show here that the Drosophila E-2...
Recent interest has centered on the capability of the brain to metabolize xenobiotics and the presence of cytochrome P450 (P450") and associated monooxygenase activity have indicated the importance of drug metabolism in the brain [1-4]. Besides P450, ravin-containing monooxygenase (FMO, EC 1.14.13.8) is also known to catalyse the oxidation of a wide variety of nitrogen-, sulphurand phosphorus-c...
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